长期应用质子泵抑制剂对非酒精性脂肪肝影响的研究进展  

Research Progress of the Effects of Long-Term Use of Proton Pump Inhibitors on Non-Alcoholic Fatty Liver Disease

作　　者：冯琳 杨朝霞[1] 

机构地区：[1]重庆医科大学附属第二医院消化内科,重庆

出　　处：《临床医学进展》2024年第4期1071-1077,共7页Advances in Clinical Medicine

摘　　要：质子泵抑制剂(PPI)是目前最常用的抑酸药物,广泛应用于酸相关胃肠道疾病。同时,PPI的合理使用以及长期使用的安全性问题受到广泛关注。近年来,有研究发现PPI的使用可能会导致肠道微生物群紊乱,增加非酒精性脂肪肝(NAFLD)的患病风险。因此,了解肠道微生物在两者之间的关系至关重要。本文总结了肠道菌群在PPI的使用及NAFLD患病中的影响,以及PPI的长期使用与NAFLD发病的关系,以引起临床医生对长期使用PPI的不良反应关注,旨在为未来基于肠道菌群调节的PPI相关的NAFLD并发症的预防提供参考。Proton pump inhibitors (PPIs) are the most commonly used acid-suppressing drugs and are widely used in acid-related gastrointestinal diseases. Meanwhile, the rational use of PPIs and the safety of long-term use have been extensively concerned. In recent years, some studies have found that PPI use may lead to gut microbiota disruption and increase the risk of non-alcoholic fatty liver disease (NAFLD). Therefore, it is crucial to find out the relationship between the gut microbiota in the two. This article summarizes the influence of gut microbiota in the use of PPIs and the prevalence of NAFLD, as well as the relationship between the long-term use of PPIs and the development of NAFLD, in order to draw the attention of clinicians to the adverse effects of long-term use of PPIs, with the aim of providing a reference for the future prevention of PPI-associated NAFLD complications based on the regulation of the intestinal microbiota.

关 键 词：质子泵抑制剂 非酒精性脂肪肝 肠道菌群 

分 类 号：R57[医药卫生—消化系统]