溃疡性结肠炎诊治现状及治疗进展  

Current Status of Diagnosis and Treatment and Progress of Treatment of Ulcerative Colitis

作　　者：郝家耀 孟存英[1] 

机构地区：[1]延安大学附属医院消化内科,陕西 延安

出　　处：《临床医学进展》2024年第4期1755-1761,共7页Advances in Clinical Medicine

摘　　要：溃疡性结肠炎是一种影响结肠的慢性炎症性疾病,其发病率及患病率在世界范围呈上升趋势。由于溃疡性结肠炎的病因及机制尚不清楚,且缺乏确切的诊断方法,因此对于UC的诊断和治疗仍面临挑战。正确的诊断和病情评估影响着UC治疗方案的选择和患者的预后。UC的药物治疗包括5-氨基水杨酸、皮质类固醇、生物制剂和小分子药物等,带有新靶点药物的出现扩大了治疗选择范围,亦有部分患者需要接受手术治疗。为达到长期治疗目标,在标准治疗的基础上辅以饮食、运动及心理干预等补充替代疗法能更好的提高缓解率,从多个层面实现整体缓解。面对出现的新的治疗方法,需要对UC患者的病情评估后制定个性化方案,为患者建立更好的收益模式。Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence and prevalence are on the rise worldwide. The diagnosis and treatment of UC remains challenging because the etiology and mechanisms of ulcerative colitis are unknown and definitive diagnostic methods are lacking. Correct diagnosis and evaluation of the disease affect the choice of treatment and prognosis for UC, which is treated with 5-aminosalicylic acid, corticosteroids, biologics, and small molecules, with the emergence of new target drugs expanding the range of therapeutic choices, and with some patients requiring surgery. In order to achieve long-term treatment goals, complementary alternative therapies such as diet, exercise and psychological interventions on top of standard treatments can improve the remission rate and achieve overall remission on multiple levels. In the face of new therapeutic approaches, it is necessary to assess the condition of UC patients and develop individualized plans to establish a better pattern of benefits for the patient.

关 键 词：溃疡性结肠炎 炎症性肠病 疾病活动性 治疗策略 生物疗法 

分 类 号：R57[医药卫生—消化系统]