帕金森病中神经血管改变与临床表型及白质损害的关系  

The Relationship among the Neurovascular Changes, Clinical Phenotypes, and White Matter Impairment in Parkinson’s Disease

作　　者：李司晨 诸玉霞 赖泓宇 达晓慧 廖婷 刘熙[1] 邓芬[1] 陈莉芬[1] 

机构地区：[1]重庆医科大学附属第二医院神经内科,重庆

出　　处：《临床医学进展》2024年第4期1908-1916,共9页Advances in Clinical Medicine

摘　　要：帕金森病包含运动症状及非运动症状,临床表现存在显著异质性,黑质纹状体系统中多巴胺能神经元退行性改变不能完全解释临床表型异质性。近年来,随着神经影像学、生物标志物等检查及检验技术的发展,帕金森病中神经血管的结构及功能改变、早期且广泛的白质损害受到了越来越多的关注。本文通过总结既往帕金森病研究中已发现的特异性神经血管结构及功能改变、不同帕金森病临床表型间神经血管结构及功能的异同点、帕金森病中神经血管改变与白质损害及临床表型的关联性,发现了帕金森病中神经血管改变可能通过白质损害对临床表型产生影响,以期促进对帕金森病临床表型、病理生理机制、临床进展及预后的认识。Parkinson’s disease, manifesting both motor and non-motor symptoms, is characterized by its clinical heterogeneity, which can not be completely attributed to mechanisms of dopaminergic neuronal degeneration in striatal-nigral systems. Nowadays, with the development of neuroimaging and biomarkers, more researches focused on structural and functional neurovascular changes as well as early and extensive white matter impairments in Parkinson’s disease. Hence, we summarized specific structural and functional neurovascular changes in Parkinson’s disease, compared similarities and differences of neurovascular changes among different clinical phenotypes of Parkinson’s disease, and discussed the relationship between neurovascular changes and white matter alterations as well as clinical phenotypes of Parkinson’s disease based on recently reported researches. And we found that neurovascular changes may influence clinical phenotypes of Parkinson’s disease mainly via white matter impairments, aiming to broaden our views concerning clinical manifestations, pathophysiological mechanisms, clinical course and prognosis of Parkinson’s disease.

关 键 词：帕金森病 神经血管改变 运动症状 非运动症状 白质损害 

分 类 号：R74[医药卫生—神经病学与精神病学]