兴奋性氨基酸与缺血性脑卒中的研究进展  

Research Progress of Excitatory Amino Acids and Ischemic Stroke

作　　者：王杜君 赵立波[1] 

机构地区：[1]重庆医科大学附属永川医院神经内科,重庆

出　　处：《临床医学进展》2024年第5期1046-1054,共9页Advances in Clinical Medicine

摘　　要：卒中是全球第二大死亡原因,在我国也是导致成人残疾、死亡的首要疾病,其中最常见的卒中类型是急性缺血性脑卒中。缺血性脑卒中(Ischemic stroke, IS)是由血管内血栓形成或栓塞引起脑血流中断,使脑血流灌注下降,主要是以突然起病、局灶性神经功能缺损为特点的急性脑血管疾病。越来越多的研究表明,代谢紊乱与IS的发生、发展密切相关。有研究结果表明,兴奋性氨基酸代谢途径异常与IS的发生、发展密切相关。本综述探讨了兴奋性氨基酸在IS中的进展,强调了其在缺血性卒中的病理生理机制及目前作为潜在治疗靶点的可能性,并为进一步研究提供参考,对兴奋性氨基酸与缺血性脑卒中进行综述。Stroke is the second leading cause of death worldwide and the leading cause of disability and death in adults in China, with the most common type of stroke being acute ischemic stroke. Ischemic stroke (IS) is an acute cerebrovascular disease characterized mainly by sudden onset and focal neurological deficits due to interruption of cerebral blood flow caused by intravascular thrombosis or embolism, resulting in decreased cerebral perfusion. More and more studies have shown that metabolic disorders are closely related to the onset and progress of IS. Studies have shown that the abnormal excitatory amino acid metabolic pathway is closely related to the occurrence and development of IS. In this review, we discuss the progress of excitatory amino acids in IS, highlight the pathophysiological mechanism of excitatory amino acids in ischemic stroke and the possibility of their being potential therapeutic targets at present, and provide reference for further research.

关 键 词：缺血性脑卒中 兴奋性氨基酸 代谢组学 研究进展 

分 类 号：R74[医药卫生—神经病学与精神病学]