非典型鳞状上皮细胞患者分流诊疗的研究进展  

Research Progress of Shunt Diagnosis and Treatment in Patients with Atypical Squamous Epithelial Cells

作　　者：李阳 徐颖[1] 刘培淑[1] 

机构地区：[1]山东大学齐鲁医院妇产科,山东 济南

出　　处：《临床医学进展》2024年第5期1205-1210,共6页Advances in Clinical Medicine

摘　　要：无明确意义的非典型鳞状上皮细胞(ASCUS)属于异常细胞范畴,其组织病理学具有不确定性和多样性,是临床中最常见也最难决定诊疗对策的细胞学检测结果。因ASCUS的特异度低,易发生诊断不足或过度诊断,故关于ASCUS患者的分流诊疗问题在临床中逐渐引起重视,并取得众多新进展。本文将从HPV基因分型、DNA定量分析、P16/Ki-67双染及PAX1甲基化在ASCUS患者分流诊疗中的临床价值入手,以期为ASCUS患者提供新的分流诊疗思路和选择。Atypical squamous cells of undetermined significance (ASCUS) belong to the category of abnormal cells. Its histopathology is uncertain and diverse, and it is the most common and difficult cytological test result to determine the diagnosis and treatment strategy in the clinic. Due to the low specificity of ASCUS, it is prone to underdiagnosis or overdiagnosis. Therefore, the problem of shunt diagnosis and treatment of ASCUS patients has gradually attracted attention in clinical practice, and much new progress has been made. This article will start with the clinical value of HPV genotyping, DNA quantitative analysis, P16/Ki-67 double staining and PAX1 methylation in the triage diagnosis and treatment of ASCUS patients, to provide new triage diagnosis and treatment ideas and choices for ASCUS patients.

关 键 词：无明确意义的非典型鳞状上皮细胞 HPV基因分型 DNA定量分析 P16/Ki-67双染 PAX1甲基化 

分 类 号：R73[医药卫生—肿瘤]