神经丝蛋白轻链在神经系统疾病中的研究现状  

The Current Research Status of Neurofilament Light Chains in Neurological Diseases

作　　者：高元浩 张卓 王雨诺 

机构地区：[1]延安大学医学院,陕西 延安 [2]咸阳市中心医院介入科,陕西 咸阳

出　　处：《临床医学进展》2024年第5期2042-2045,共4页Advances in Clinical Medicine

摘　　要：轴突中高度集中表达的神经元细胞内蛋白质,神经丝蛋白轻链(neurofilament light chain, NfL),是检测轴突损害的灵敏指标。识别及定量轴突损伤对于评判神经系统病症的活跃度、追踪治疗效果以及预测疾病走向尤为关键。不同神经系统病症引起的轴突损害程度与脑脊液和血清中的神经丝蛋白轻链水平成正相关。利用新型免疫检测技术,能够在极低浓度下定量监测这些生物标志物,进而通过血液中的神经丝蛋白轻链水平来追踪疾病进程。因此,本篇文章综述了神经丝蛋白的结构与作用,并分析了其与神经系统病变之间的联系。The neuronal intracellular proteins that are highly expressed in axons, neurofilament light chains (NfL), are sensitive markers for the detection of axonal damage. Identifying and quantifying axonal injuries are crucial for assessing the activity of neurological diseases, monitoring therapeutic effects, and predicting disease progression. The extent of axonal damage caused by different neurological disorders correlates positively with the levels of neurofilament light chains in cerebrospinal fluid and serum. Utilizing advanced immunodetection techniques, these biomarkers can be quantitatively monitored at very low concentrations, thereby tracking the disease progression through the levels of neurofilament light chains in blood. Therefore, this article reviews the structure and function of neurofilaments and analyzes their relationship with neurological pathologies.

关 键 词：神经丝蛋白 神经丝轻链 神经系统疾病 综述 

分 类 号：R74[医药卫生—神经病学与精神病学]