外泌体miRNA在肝癌中的诊治进展  

Advances in the Diagnosis and Treatment of Exosomal miRNA in Liver Cancer

作　　者：谭聪聪 戴毅[2] 余华 

机构地区：[1]成都中医药大学医学与生命科学学院,四川 成都 [2]遂宁市中心医院肝胆外科,四川 遂宁 [3]成都中医药大学附属医院普外科,四川 成都

出　　处：《临床医学进展》2024年第5期2093-2102,共10页Advances in Clinical Medicine

摘　　要：肝癌(liver cancer)是全球危害人类健康的主要癌症之一,具有发病隐匿、恶性程度高、治疗效果及预后差等特点。外泌体(Exosomes)是细胞间通讯的重要载体,是细胞分泌的囊泡,包含蛋白质、miRNA、mRNA等。近年来,大量研究表明外泌体microRNA (miRNA)在肝癌发生发展不同时期呈现不同表达,因此miRNA被认为是肝癌诊断和治疗极具潜力的生物标志物。本文就miRNA作为诊断与治疗的生物标志物在肝癌发展的各阶段最新研究进展进行综述。重点介绍miRNA在肝癌的诊断、治疗及其预后方面的研究进展。Liver cancer is one of the major cancers jeopardizing human health worldwide, characterized by insidious onset, high degree of malignancy, and poor therapeutic effect and prognosis. Exosomes are important carriers of intercellular communication and are vesicles secreted by cells that contain proteins, miRNAs, mRNAs and so on. In recent years, a large number of studies have shown that exosomal microRNAs (miRNAs) are differently expressed at different periods of liver cancer development, and thus miRNAs are considered to be highly promising biomarkers for liver cancer diagnosis and treatment. This article provides a review of the latest research advances on miRNAs as biomarkers for diagnosis and treatment at various stages of liver cancer development and focuses on the research progress of miRNAs in the diagnosis and treatment of liver cancer and their prognosis.

关 键 词：肝癌 外泌体 MICRORNA 乙肝相关性肝癌 早期诊断 靶向治疗 

分 类 号：R73[医药卫生—肿瘤]