免疫细胞在缺血性脑卒中后神经功能修复的研究  

Research of Immune Cells in Neural Function Repair after Ischemic Stroke

作　　者：郭雪娟 梅利 

机构地区：[1]青海大学研究生院,青海 西宁 [2]西宁市第一人民医院神经内科,青海 西宁

出　　处：《临床医学进展》2024年第6期18-24,共7页Advances in Clinical Medicine

摘　　要：缺血性脑卒中是最常见的脑卒中类型,发病率、致残率、死亡率均处于较高的水平。近年来免疫应答成为缺血性脑卒中治疗策略中的一个新的突破靶点。研究表明,免疫细胞参与了缺血性脑卒中早期损伤到晚期恢复过程的多个方面。本文阐述了主要免疫细胞(小胶质细胞、星形胶质细胞、周细胞、中性粒细胞、单核细胞/巨噬细胞和T淋巴细胞)在缺血性脑卒中后介导的神经功能恢复机制,以及免疫细胞之间的相互作用对神经功能恢复的影响,为改善神经功能的新疗法提供线索。Ischemic stroke is the most common type of stroke with high morbidity, disability and mortality. In recent years, immune response has become a new breakthrough target in the treatment strategy of ischemic stroke. Studies have shown that immune cells are involved in multiple aspects of the recovery process from early injury to late recovery in ischemic stroke. In this paper, the mechanism of nerve function recovery mediated by major immune cells (microglia, astrocytes, pericytes, neutrophils, monocytes/macrophages and T lymphocytes) after ischemic stroke and the influence of the interaction between immune cells on nerve function recovery are described, providing clues for new therapies to improve nerve function.

关 键 词：免疫细胞 细胞间相互作用 缺血性脑卒中 神经功能修复 

分 类 号：R74[医药卫生—神经病学与精神病学]