CD44的生物特征及在恶性肿瘤中的研究进展  

Biological Characterization of CD44 and Progress in Malignant Tumors

作　　者：田思岳 范志勤[1] 

机构地区：[1]新疆医科大学附属肿瘤医院日间病房(三病区),新疆 乌鲁木齐

出　　处：《临床医学进展》2024年第6期1490-1494,共5页Advances in Clinical Medicine

摘　　要：CD44是一种复杂的跨膜糖蛋白,在肿瘤干细胞上过度表达。CD44表达失调与肿瘤发生和发展有关。CD44参与多种重要信号通路的调控,与肿瘤增殖、侵袭、转移和治疗耐药密切相关。CD44过度表达抑制化疗药物在多种癌症中的细胞毒作用。因此,CD44可以作为癌症患者的不良预后标志物。CD44过度表达为化疗耐药患者的治疗干预提供新的分子靶点。本篇综述重点概述CD44的结构功能,CD44在肿瘤细胞干性和肿瘤发生发展中的作用,及与癌症患者预后的关系。CD44 is a complex transmembrane glycoprotein that is overexpressed on tumor stem cells. Dysregulated CD44 expression is associated with tumorigenesis and progression. CD44 is involved in the regulation of multiple important signaling pathways and is closely related to tumor proliferation, invasion, metastasis, and therapeutic resistance. CD44 overexpression inhibits the cytotoxic effects of chemotherapeutic agents in multiple cancers. Therefore, CD44 can be used as a poor prognostic marker for cancer patients. CD44 overexpression provides new molecular targets for therapeutic intervention in chemotherapy-resistant patients. This review focuses on an overview of the structure and function of CD44, the role of CD44 in tumor cell stemness and tumorigenesis and development, and its relationship to the prognosis of cancer patients.

关 键 词：CD44 恶性肿瘤 癌症干细胞 预后 

分 类 号：R73[医药卫生—肿瘤]