Hsp90α在癌症中的发展与治疗的研究进展  

Research Progress on the Role of Hsp90α in Cancer Development and Treatment

作　　者：常思远 王晓燕[2] 熊涛 史光军[4] 

机构地区：[1]青岛大学医学部,山东 青岛 [2]青岛市市立医院国际门诊,山东 青岛 [3]山东第二医科大学临床医学院,山东 潍坊 [4]青岛市市立医院东院肝胆胰外科,山东 青岛

出　　处：《临床医学进展》2024年第7期746-755,共10页Advances in Clinical Medicine

摘　　要：Hsp90 (Heat Shock Protein 90)是一种在细胞应激条件下诱导表达的分子伴侣蛋白,在发现其可以作为癌症的诊断手段及治疗靶点后,其研究迎来了井喷式的发展。已有研究表明,Hsp90α不仅与肿瘤细胞的生存、增殖和迁移有关,还参与了肿瘤微环境的调控,其高表达与多种癌症类型的不良预后显著相关。近期的研究表明,p53也与Hsp90α拥有复杂而密切的联系,二者之间的交互作用对肿瘤的发生发展有十分重要的作用。在本综述中,我们将探讨Hsp90α在癌症发生和治疗中的作用,关注其与p53这一关键肿瘤抑制蛋白的相互作用。Hsp90 (Heat Shock Protein 90) is a molecular chaperone induced under cellular stress conditions. Since its discovery as a diagnostic tool and therapeutic target for cancer, research on Hsp90 has experienced explosive growth. Studies have shown that Hsp90α is not only involved in the survival, proliferation, and migration of tumor cells but also in the regulation of the tumor microenvironment. Furthermore, its high expression is significantly associated with poor prognosis in various types of cancer. Recent research indicates that p53 also has a complex and close relationship with Hsp90α, and their interactions play a crucial role in tumorigenesis. In this review, we will explore the role of Hsp90α in cancer development and treatment, focusing on its interactions with p53, a key tumor suppressor protein.

关 键 词：HSP90Α 癌症 癌症治疗 肿瘤代谢 P53 诊断 

分 类 号：R73[医药卫生—肿瘤]