HLA-B*15:02与芳香族类抗癫痫药物诱发SJS/TEN关联性的Meta分析  

Meta-Analysis of the Association of HLA-B*15:02 with Aromatic Antiepileptic Drugs Inducing SJS/TEN

作　　者：魏翼 林意菊 陈路琼 秦春凤 姚凯云 

机构地区：[1]大理大学药学院,云南 大理 [2]大理市第一人民医院药学实验室,云南 大理

出　　处：《临床医学进展》2024年第9期869-878,共10页Advances in Clinical Medicine

摘　　要：目的:通过meta分析来评估HLA-B*15:02等位基因与芳香族类抗癫痫药物(AEDs)诱发史蒂文斯–约翰逊综合征/中毒性表皮坏死松解症(SJS/TEN)的关联。方法:全面检索PubMed、Embase、The Cochrane Library、知网、万方、维普数据库,检索时间截止2024年7月1日,采用Revman5.3软件进行meta分析。结果:共纳入26篇文献,均为病例对照研究,共计芳香族类AEDs诱发SJS/TEN患者794例,对照2851例,分析结果合并为OR (95% CI)为26.32 (15.67~44.21) (Z = 12.36, P Objective: To assess the association of HLA-B*15:02 allele with aromatic antiepileptic drugs (AEDs) induced Stevens-Johnson syndrome/toxic epidermal necrolysis with laxity (SJS/TEN) by meta-analysis. Methods: A comprehensive search of PubMed, Embase, The Cochrane Library, Zhi.com, Wanfang, and Wipu databases was performed up to 1 July 2024, and meta-analysis was performed using Revman 5.3 software. Results: A total of 26 papers, all of which were case-control studies, were included, with a total of 794 patients with SJS/TEN induced by aromatic AEDs and 2851 controls, and the combined results of the analyses showed an OR (95% CI) of 26.32 (15.67~44.21) (Z = 12.36, P < 0.00001). Conclusion: There was a significant association of HLA-B*1502 allele eliciting AEDs of the Fragrant family class causing SJS/TEN.

关 键 词：芳香族抗癫痫药物 白细胞抗原 META分析 

分 类 号：R74[医药卫生—神经病学与精神病学]