血清SIL-2R、HCY与妊娠期亚临床甲状腺功能减退症及其妊娠结局的关系分析  

Analysis of the Relationship between Serum SIL-2R, HCY and Subclinical Hypothyroidism during Pregnancy and Pregnancy Outcome

作　　者：居来提·阿扎提 马涛[1] 

机构地区：[1]新疆医科大学第二附属医院检验科,新疆 乌鲁木齐

出　　处：《临床医学进展》2024年第10期1361-1367,共7页Advances in Clinical Medicine

摘　　要：目的:分析妊娠期亚临床甲状腺功能减退症(SCH)孕妇血清可溶性白细胞介素-2受体(SIL-2R)、同型半胱氨酸(HCY)的表达意义及与妊娠结局的关系。方法:选择我院自2021年1月至2023年6月收治的120例妊娠期SCH孕妇(观察组)及120例正常妊娠孕妇(对照组);检测两组血清SIL-2R、HCY表达水平,分析血清SIL-2R、HCY与促甲状腺激素(TSH)的关系,通过受试者工作特征曲线(ROC)下面积(AUC)评价观察组血清SIL-2R联合HCY对妊娠结局不良的预测效能。结果:观察组妊娠期碘摄入量偏少比例、TPOAb阳性率和TGAb阳性率均高于对照组,差异均有统计学意义(P Objective: To analyze the expression significance of serum soluble interleukin-2 receptor (SIL-2R) and homocysteine (HCY) in pregnant women with subclinical hypothyroidism (SCH) during pregnancy and their relationship with pregnancy outcome. Methods: 120 SCH pregnant women (observation group) and 120 normal pregnant women (control group) admitted to our hospital from January 2021 to June 2023 were selected. The expression levels of serum SIL-2R and HCY in the two groups were detected, and the relationship between serum SIL-2R and HCY and thyroid stimulating hormone (TSH) was analyzed. The predictive efficacy of serum SIL-2R combined with HCY in the observation group was evaluated by area under receiver operating characteristic curve (ROC) (AUC). Results: The proportion of low iodine intake, TPOAb positive rate and TGAb positive rate in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). The expression levels of serum SIL-2R and HCY in observation group were higher than those in control group, and the differences were statistically significant (P < 0.05). By Pearson correlation analysis, serum SIL-2R and HCY expression levels of SCH pregnant women were positively correlated with TSH (P < 0.05). Logistic regression analysis showed that low iodine intake and high levels of serum

关 键 词：妊娠期 亚临床甲状腺功能减退症 可溶性白细胞介素-2受体 同型半胱氨酸 妊娠结局 

分 类 号：R73[医药卫生—肿瘤]