脐带血单个核细胞在肝病治疗中的应用前景  

The Application Prospects of Umbilical Cord Blood Mononuclear Cells in the Treatment of Liver Diseases

作　　者：刘雪纯 荆雪[1] 

机构地区：[1]青岛大学附属医院消化内科,山东 青岛

出　　处：《临床医学进展》2024年第11期888-893,共6页Advances in Clinical Medicine

摘　　要：脐带血单个核细胞(Umbilical cord blood-mononuclear cells, UCB-MNCs)由于其独特的干细胞来源及显著的免疫调节特性,近年来在肝病治疗领域引起了广泛的关注。肝病,尤其是肝纤维化、肝炎和肝癌,已成为全球公共健康面临的重大挑战。尽管传统治疗方法的效果有限,UCB-MNCs凭借其再生与修复的潜力,展现出良好的临床应用前景。本文旨在深入分析UCB-MNCs在肝病治疗中的应用现状,探讨其作用机制,回顾相关临床研究的进展,并展望未来的发展方向。通过对相关文献的系统性梳理,我们揭示了UCB-MNCs在促进肝脏再生及免疫调节中的关键作用,展望了未来研究的潜在方向,以期为UCB-MNCs在肝病治疗中的应用提供更为明确的指导。Umbilical cord blood mononuclear cells (UCB-MNCs), due to their unique stem cell source and significant immunomodulatory properties, have garnered widespread attention in recent years in the field of liver disease treatment. Liver diseases, especially liver fibrosis, hepatitis, and liver cancer, have become major challenges in global public health. Although the effects of traditional treatment methods are limited, UCB-MNCs show promising clinical potential with their regenerative and reparative capabilities. This paper aims to analyze the current applications of UCB-MNCs in liver disease treatment, explore their mechanisms of action, review the progress of related clinical studies, and look ahead to future developments. By systematically reviewing relevant literature, we highlight the key roles of UCB-MNCs in promoting liver regeneration and immunomodulation, and anticipate potential directions for future research, providing clearer guidance for the application of UCB-MNCs in liver disease treatment.

关 键 词：脐带血单个核细胞 肝病 干细胞 肝纤维化 免疫治疗 

分 类 号：R57[医药卫生—消化系统]