PI3K/AKT信号通路在心肌病中应用的研究进展  

Research Advances in the Application of PI3K/AKT Signaling Pathway in Cardiomyopathy

作　　者：向仲双 申强 

机构地区：[1]南华大学附属怀化医院,湖南 衡阳 [2]湖南医药学院总医院,心血管内科,湖南 怀化

出　　处：《临床医学进展》2024年第11期51-56,共6页Advances in Clinical Medicine

摘　　要：磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B (AKT)通路作为信号通路中的明星通路之一,在各个领域均发挥重要作用,如心血管疾病、肿瘤、内分泌系统疾病及其他全身系统疾病等。研究发现PI3K/AKT信号通路参与细胞的生长、代谢、凋亡及糖脂代谢等途径,有进一步研究表明PI3K/AKT信号通路是影响代谢性心血管疾病发病和进展的重要通路之一。深入探究PI3K/AKT信号通路在心肌病中的作用机制,对心肌病的预防、治疗及预后评估具有一定的临床价值。Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway, as one of the star signaling pathways, plays an important role in various fields, such as cardiovascular diseases, tumors, endocrine system diseases and other systemic diseases. Studies have found that PI3K/AKT signaling pathway is involved in cell growth, metabolism, apoptosis, glucose and lipid metabolism, and other pathways. Further studies have shown that PI3K/AKT signaling pathway is one of the important pathways affecting the pathogenesis and progression of metabolic cardiovascular diseases. Further exploration of the mechanism of PI3K/AKT signaling pathway in cardiomyopathy has certain clinical value for the prevention, treatment and prognosis evaluation of cardiomyopathy.

关 键 词：PI3K AKT 扩张性心肌病 糖尿病心肌病 肥厚性心肌病 其他类型心肌病 

分 类 号：R73[医药卫生—肿瘤]