MUC20与肿瘤关联性研究  

Study on MUC20 and Tumor Association

作　　者：严励 许文浩 和新瑜 陈若冰 刘为青[1] 

机构地区：[1]昆明医科大学附属第一医院肿瘤内科,云南 昆明 [2]昆明医科大学附属第一医院肿瘤外科,云南 昆明

出　　处：《临床医学进展》2024年第12期33-46,共14页Advances in Clinical Medicine

摘　　要：MUC20是由上皮组织分泌的高分子量糖蛋白,是粘蛋白的一种。作为新近被发现的粘蛋白,MUC20在结肠、食管、胆囊、肾脏、膀胱等正常组织中均有表达,而相关研究表明其参与组织器官的保护、信号传递等活动。另外,随着对该粘蛋白的研究逐渐增加,目前已证实其在多种病变的器官、组织中存在,且与相应器官肿瘤的发生发展密切相关,如胰腺癌、结直肠癌、胃癌、子宫内膜癌、卵巢癌、膀胱癌等。本文将介绍MUC20的蛋白结构、功能位点、组织表达情况,此外还将分系统综述MUC20粘蛋白及与MUC20密切相关的粘蛋白和各系统器官恶性肿瘤之间的关联,并提出一定的见解,为以后的相关研究提供相关思路。MUC20 is a high-molecular-weight glycoprotein secreted by epithelial tissues and is a type of mucin. As a newly discovered mucin, MUC20 is expressed in normal tissues such as the colon, esophagus, gallbladder, kidney, and bladder, and related studies have shown that it is involved in the protection of tissues and organs, signaling and other activities. In addition, with the gradual increase of research on mucin, it has been found that mucin exists in a variety of diseased organs and tissues, and is closely related to the occurrence and development of tumors in corresponding organs, such as pancreatic cancer, colorectal cancer, gastric cancer, endometrial cancer, ovarian cancer, bladder cancer, etc. In this article, we will introduce the protein structure, functional sites, and tissue expression of MUC20, and systematically review the association between MUC20 and mucins closely related to MUC20 and malignant tumors of various systems and organs, and put forward some insights to provide relevant ideas for future related research.

关 键 词：粘蛋白 MUC20 肿瘤学 肿瘤细胞 

分 类 号：R73[医药卫生—肿瘤]