红细胞与骨创伤患者深静脉血栓形成研究进展  

The Research Advancements in Deep Vein Thrombosis among Patients with Erythrocyte and Bone Trauma

作　　者：成佩瑶 程波[1] 

机构地区：[1]重庆医科大学附属第一医院麻醉科,重庆

出　　处：《临床医学进展》2024年第12期502-510,共9页Advances in Clinical Medicine

摘　　要：红细胞一直被视为血栓形成的旁观者,然而越来越多的临床和实验室证据表明红细胞在血栓形成和止血过程中扮演着积极角色。本综述对骨创伤患者深静脉血栓形成中红细胞的作用进行了全面综合分析。临床和流行病学研究已经证实,红细胞相关指标异常,如血细胞比容、红细胞分布宽度和红细胞平均体积变化等,在血栓性疾病的发生和预测方面具有较高的价值。骨创伤患者术前贫血的发生率相当高,且可能导致大量失血,从而增加围手术期输注红细胞的风险。在贫血患者和接受红细胞输注的患者中,红细胞异常与深静脉血栓形成密切相关。通过对血液流变学、凝血过程以及内皮细胞、血小板、纤维蛋白原和中性粒细胞等因素的影响,红细胞可以促进深静脉血栓生成。Red blood cells have traditionally been considered as passive bystanders in thrombosis, however, there is mounting clinical and laboratory evidence indicating an active role of red blood cells in the processes of thrombosis and hemostasis. This comprehensive review thoroughly examines the involvement of red blood cells in deep vein thrombosis among patients with bone trauma. Clinical and epidemiological studies have substantiated that abnormal erythrocyte-related indicators, such as hematocrit, erythrocyte distribution width, and mean erythrocyte volume alteration, hold significant predictive value for the occurrence of thrombotic diseases. The incidence of preoperative anemia is notably high among patients with bone trauma, which can result in substantial blood loss thereby elevating the risk for perioperative red blood cell transfusions. Remarkably, red blood cell abnormalities exhibit a strong association with deep vein thrombosis not only in individuals with anemia but also in those who undergo red blood cell transfusions. By exerting influence on hemorheology, coagulation process, endothelial cells, platelets fibrinogen levels, and neutrophils act

关 键 词：红细胞 深静脉血栓形成 骨创伤 

分 类 号：R73[医药卫生—肿瘤]