外周血CD8+T细胞对肝细胞癌术后预后的价值研究  

Study on the Prognostic Value of Peripheral Blood CD8+T Cells in Hepatocellular Carcinoma after Curative Hepatectomy

作　　者：孙浩然 曹泽鹏 赵宝晨 万得晨 周大臣[1] 陈忠彪 张彬 

机构地区：[1]安徽医科大学第二附属医院普外科,安徽 合肥

出　　处：《临床医学进展》2025年第1期507-516,共10页Advances in Clinical Medicine

摘　　要：目的:外周免疫景观可能在肝细胞癌(HCC)的识别和控制中起关键作用。本研究旨在探讨外周血CD8+T细胞数量在预测肝细胞癌根治性肝切除术后预后中的价值。方法:选取2018年8月至2023年7月79例于我院行根治性肝切除术的初诊HCC患者作为研究对象,分析外周血CD8+T细胞数量对患者预后的预测价值。流式细胞术检测CD8+T细胞数量。结果:CD8+T细胞数量在早期复发和死亡患者中明显减少(p Cox回归分析显示CD8+T细胞数量是术后预后的独立影响因素(p Objective: The peripheral immune landscape may play a key role in determining hepatocellular carcinoma (HCC) recognition and control. This study aimed to examine the utility of peripheral blood CD8+T cells in predicting prognosis in HCC after curative hepatectomy. Methods: 79 newly diagnosed HCC patients from August 2018 to July 2023 were selected as research objects, we analyzed the prognostic value of peripheral blood CD8+T cells of HCC patients who underwent curative hepatectomy. The number of CD8+T cells was detected by flow cytometry. Results: The number of CD8+T cells was significantly decreased in patients who developed recurrence and death (all p Cox regression demonstrated that the number of CD8+T cells was an independent indicator for poor prognosis after hepatectomy (both p < 0.050). The recurrence-free survival (RFS) and overall survival (OS) in decrease group were significantly shorter than non-decrease group. The results were confirmed by the subgroup analysis. Conclusion: The number of CD8+T cells in peripheral blood is associated with dismal outcomes in HCC patients and can serve as a novel prognostic indicator for HCC patients after curative hepatectomy.

关 键 词：CD8+T细胞 肝细胞癌 肝切除术 早期复发 预后 

分 类 号：R73[医药卫生—肿瘤]