某三甲医院耐碳青霉烯类铜绿假单胞菌感染患者的临床特征及危险因素  

Clinical Characteristics and Risk Factors of Carbapenem-Resistant Pseudomonas Aeruginosa Infection in a Tertiary Hospital

作　　者：高喆 赵京明[2] 

机构地区：[1]青岛大学青岛医学院,山东 青岛 [2]青岛大学附属医院呼吸与危重症医学科,山东 青岛

出　　处：《临床医学进展》2025年第1期1778-1784,共7页Advances in Clinical Medicine

基　　金：山东省医药卫生科技发展计划项目:2019WS377血红素氧化酶HemO抑制剂调控铜绿假单胞菌耐药性及毒力基因表达研究。

摘　　要：目的:探讨某三甲医院耐碳青霉烯类铜绿假单胞菌感染患者的临床特征及危险因素。方法:回顾性分析2017年10月~2022年10月某三甲医院住院治疗的52例CRPA患者的临床资料及菌株药敏数据,分析结果差异、临床特征和危险因素。结果:52例CRPA感染患者中,男性38例(73.08%),男女比例为2.7:1;平均年龄65 ± 14岁;科室最常见于呼吸与危重症医学科17例(32.69%),其次是重症医学科12例(23.08%);标本主要来源于痰液40例(76.92%);对于基础疾病,合并贫血患者36例(69.23%),呼吸系统疾病34例(65.38%),心脑血管系统疾病30例(57.69%);近2月抗生素的使用情况,使用碳青霉烯类抗生素的有34例(65.38%);半合成β内酰胺酶复合制剂31例(59.62%);52株CRPA中耐药率 ≥ 50%的抗菌药物从高到低依次为亚胺培南、美洛培南,多粘菌素是耐药率最低且药物敏感率最高的抗菌药物。结论:52例CRPA患者表明男性患者、住院时间过长、合并贫血及呼吸系统疾病、近2月内碳青霉烯类抗菌药物应用史均会增加感染耐药菌的风险,控制危险因素、缩短住院时长以及合理应用抗生素可以减少多重耐药菌感染。Objective: The objective of this study was to investigate the clinical features and risk factors associated with carbapenem-resistant pseudomonas aeruginosa (CRPA) infection in a tertiary hospital. Methods: Retrospective analysis was conducted on the clinical and bacterial susceptibility data of 52 CRPA-infected patients hospitalized from October 2017 to October 2022. Results: Clinical characteristics and risk factors were analyzed for differences. Among the 52 CRPA-infected patients, 38 (73.08%) were male with a male-to-female ratio of 2.7:1. The average age was 65 ± 14 years, the department is most commonly found in the Respiratory and Critical Care Medicine department with 17 cases (32.69%), followed by the Intensive Care Medicine department with 12 cases (23.08%). Sputum was the primary source of infection

关 键 词：铜绿假单胞菌 耐碳青霉烯类 下呼吸道感染 临床特征 危险因素 

分 类 号：R73[医药卫生—肿瘤]