感染性休克使用特利加压素还是去甲肾上腺素?  

Teripressin Is Used in Septic Shock Still Norepinephrine?

作　　者：刘澳 王君艳[2] 

机构地区：[1]内蒙古医科大学包头临床医学院,内蒙古 包头 [2]包头市中心医院重症医学科,内蒙古 包头

出　　处：《临床医学进展》2025年第2期50-54,共5页Advances in Clinical Medicine

基　　金：内蒙古医学科学院公立医院科研联合基金项目。

摘　　要：背景:全球脓毒症休克的发病率和死亡率居高不下,尽管去甲肾上腺素可以增加危重病人的血压,但对额外治疗的需求未得到满足。方法:特利加压素与去甲肾上腺素治疗感染性休克的多中心随机对照试验来解决这个问题。结果:将617例患者随机分配到特利加压素(n = 312)或去甲肾上腺素输注(n = 305)联合标准治疗组,其中包括开放标签血管加压药。对主要终点,即亚组28天死亡率(特利加压素n = 260;去甲肾上腺素n = 266)进行了先验改良的意向治疗初步分析。28天死亡率无差异(特利加压素 = 40%,去甲肾上腺素 = 38%,p NS)。选定的次要终点,如存活天数和无血管加压药天数以及脓毒症器官衰竭评估(SOFA)评分的变化,组间没有差异。然而,特利加压素组的不良事件比去甲肾上腺素组更严重(30% vs. 12%, P Background: The incidence and mortality of septic shock remain high globally, and although norepinephrine can increase blood pressure in critically ill patients, there is an unmet need for additional treatment. Methods: A multicenter randomized controlled trial of teripressin versus norepinephrine for septic shock was conducted to address this issue. Results: 617 patients were randomly assigned to teripressin (n = 312) or norepinephrine infusion (n = 305) in combination with standard care, which included open-label vasopressors. For the primary endpoint, the subgroup 28-day mortality (teripressin n = 260;Norepinephrine n = 266) performed a preliminary analysis of intention-to-treat with a priori modification. There was no difference in mortality at 28 days (teripressin = 40%, norepinephrine = 38%, pNS). Selected secondary endpoints, such as days of survival and vasopressor free days and changes in the Sepsis Organ Failure Assessment (SOFA) score, did not differ between groups. However, adverse events were more severe in the teripressin group than in the norepinephrine group (30% vs. 12%, P < 0.01). Conclusions: There was no difference

关 键 词：特利加压素 去甲肾上腺素 感染性休克 联合治疗 

分 类 号：R73[医药卫生—肿瘤]