转录因子MYBL2在恶性肿瘤中的研究进展  

Research Progress of Transcription Factor MYBL2 in Malignant Tumors

作　　者：景佩缜 王脉 韩睿文 张旭东 陈蕊[3] 

机构地区：[1]西安医学院研究生工作部,陕西 西安 [2]西安医学院临床医学院,陕西 西安 [3]西安医学院第一附属医院妇产科,陕西 西安

出　　处：《临床医学进展》2025年第2期76-82,共7页Advances in Clinical Medicine

摘　　要：成髓细胞瘤转录因子第2亚型(MYB proto-oncogene like 2, MYBL2)是MYB转录因子家族的成员,参与多种细胞的增殖、分化、凋亡。近年来,MYBL2作为一种转录调节因子,被发现其在肿瘤、炎性疾病等疾病中具有重要作用。一方面,MYBL2直接与启动子结合区域结合,另一种通过与其他蛋白质相互作用结合。随着研究的深入,MYBL2在恶性肿瘤中的调控作用及分子机制逐步被揭示,但在不同肿瘤中的调控效应不尽相同。现在还需进一步研究MYBL2在各种恶性肿瘤中的调节机制,在未来MYBL2有成为恶性肿瘤的治疗靶点可能。本文根据近年恶性肿瘤中MYBL2的作用及其分子机制展开综述,为今后的研究提供新思路。MYB proto-oncogene like 2 (MYBL2) is a member of the MYB transcription factor family and is involved in the proliferation, differentiation and apoptosis of various cells. In recent years, MYBL2, as a transcriptional regulator, has been found to play an important role in tumors, inflammatory diseases and other diseases. On one hand, MYBL2 binds directly to promoter binding regions, and the other binds by interacting with other proteins. With the deepening of research, the regulatory role and molecular mechanism of MYBL2 in malignant tumors have been gradually revealed, but the regulatory effect in different tumors is not the same. It is still necessary to further study the regulatory mechanism of MYBL2 in various malignant tumors, and MYBL2 may become a therapeutic target for malignant tumors in the future. In this paper, we reviewed the role and molecular mechanism of MYBL2 in malignant tumors in recent years, providing new ideas for future research.

关 键 词：MYBL2 恶性肿瘤 信号通路 治疗靶点 

分 类 号：R73[医药卫生—肿瘤]