金黄色葡萄球菌群体感应系统及毒力调控机制  

Quorum Sensing System and Virulence Regulation Mechanism of Staphylococcus aureus

作　　者：张晨晨 田代印[1] 

机构地区：[1]重庆医科大学附属儿童医院呼吸科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿童代谢与炎症性疾病重庆市重点实验室,儿童感染与免疫罕见病重庆市重点实验室,重庆

出　　处：《临床医学进展》2025年第2期867-873,共7页Advances in Clinical Medicine

基　　金：重庆市自然科学基金面上项目:CSTB2022NSCQ-MSX0822,重庆医科大学未来医学青年创新团队支持计划:W0063。

摘　　要：辅助基因调控(agr)群体感应系统通过调控毒力因子及生物被膜形成等影响金黄色葡萄球菌毒力的表达。agr的信号传导主要依赖于自诱导信号肽(AIP)与AgrC结合后激活AgrA,而后直接由AgrA或转录后调节因子RNAIII作用于下游靶基因调控金黄色葡萄球菌的毒力因子。本综述主要讲述了AIP与AgrC结合以及AgrA作用于下游靶基因的机制。讨论了agr阴性突变菌株感染对临床患者的影响,还讨论了多种毒力调控基因与agr共同作用调节金葡菌毒力的复杂网络。Accessory gene regulator (agr) quorum sensing network affects the expression of Staphylococcus aureus virulence by regulating virulence factors and biofilm formation. The signal transduction of agr mainly depends on the activation of AgrA after the binding of AIP with AgrC, and then the direct action of AgrA or the post-transcriptional regulatory factor RNAIII on the downstream target gene to regulate the virulence factors of Staphylococcus aureus. This review mainly describes the mechanism of AIP binding to AgrC and AgrA acting on downstream target genes. The effects of agr negative mutant strains on clinical patients were discussed, and the complex network of virulence regulation genes and agr regulating Staphylococcus aureus was discussed.

关 键 词：金黄色葡萄球菌 agr基因 毒力调控系统 

分 类 号：R73[医药卫生—肿瘤]