MHD患者血Hcy、PTH、β2-MG与认知障碍的相关性研究  

A Study on the Correlation between Hcy, PTH, β2-MG and Cognitive Im-pairment in Maintenance Hemodialysis Patients

作　　者：李晓莉 巴应贵[1] 

机构地区：[1]青海大学附属医院,青海 西宁

出　　处：《亚洲急诊医学病例研究》2023年第2期47-52,共6页Asian Case Reports in Emergency Medicine

摘　　要：认知障碍在慢性肾脏病(chronic kidney disease, CKD)患者的所有阶段都很常见,大多数接受维持性血液透析(maintenance hemodialysis, MHD)治疗的终末期肾病(end stage renal disease, ESRD)患者通常患有某种程度的认知功能障碍,这会损害他们的服药依从性和生活质量,认知障碍可能导致长期的不良后果,包括痴呆和死亡。与普通人群相比,MHD患者轻度认知障碍(mild cognitive im-pairment, MCI)患病率较高,据报道接受血液透析的ESRD患者认知障碍发生率高达70%,MCI被认为是MHD患者全因死亡率的独立预测因子。因此,积极控制MHD患者认知障碍的危险因素,早发现、早干预对于提高MHD患者生活质量有重要意义。Cognitive impairment is common in all stages of chronic kidney disease (CKD) patients, and most end-stage renal disease (ESRD) patients who re-ceive maintenance hemodialysis (MHD) treatment typically suffer from some degree of cognitive impairment, which can impair their medication adherence and quality of life. Cognitive impairment may lead to long-term adverse consequences, Including dementia and death. Compared with the general population, MHD patients have a higher incidence of mild cognitive impairment (MCI), with a reported incidence of 70% in ESRD patients undergoing hemodialysis. MCI is considered an inde-pendent predictor of all-cause mortality in MHD patients. Therefore, actively controlling the risk factors of cognitive impairment in MHD patients, early detection and intervention are of great sig-nificance for improving the quality of life of MHD patients.

关 键 词：维持性血液透析 同型半胱氨酸 甲状旁腺激素 Β2-微球蛋白 认知障碍 

分 类 号：R74[医药卫生—神经病学与精神病学]