临床上念珠菌耐药性发生的研究进展  

The Research Progress on Occurrence of Candida Drug Resistance

作　　者：付婉瑞 李凌志 钟鑫 胡莺菡 朱晓凤 宋章永 

机构地区：[1]西南医科大学基础医学院,四川泸州

出　　处：《微生物前沿》2017年第4期98-107,共10页Advances in Microbiology

基　　金：大学生创新创业训练项目(No.2017035和No.201710632005)。

摘　　要：近年来,临床上以念珠菌为代表的侵袭性真菌感染的发病率和致死率呈急剧上升趋势,且临床菌株的耐药性也随之发生且日益严重。本文综述了念珠菌的临床症状、检验技术的发展、耐药菌株的发生和耐药机理研究现状和抗真菌药物的使用和开发,为诊断和治疗临床上日益严重的念珠菌病提供依据。In recent years, the morbidity and mortality of candidiasis are increasing rapidly. At the same time, the extensive use of antifungal agents has led to the development of drug-resistant strains. This review summarizes the clinical symptoms, the development of detection methods, the development and resistance mechanism of drug-resistant strains, and the development and usage of antifungal agents so as to provide a basis for diagnosis and treatment of candidiasis.

关 键 词：念珠菌病 多重耐药性 耐药机理 

分 类 号：R73[医药卫生—肿瘤]