自噬作为多种疾病治疗的靶点  

Autophagy as a Therapeutic Target for Multiple Diseases

作　　者：宋明慧 邱小波 

机构地区：[1]中国药科大学,生命科学与技术学院,江苏 南京 [2]北京师范大学,生命科学学院,细胞增殖与调控生物学教育部重点实验室,北京

出　　处：《生物过程》2024年第2期98-104,共7页Bioprocess

摘　　要：自噬是一种溶酶体降解途径,可降解错误折叠的蛋白质、清除不必要或损伤的细胞器并消除感染的病毒或细菌等病原体,从而维持真核细胞的稳态。自噬对于细胞生存、生物能稳态、机体发育至关重要,与许多人类疾病的发生发展密切相关。本综述总结了自噬在癌症和神经退行性疾病中作用的研究进展,并讨论了靶向自噬的潜在疾病治疗方法。Autophagy is a lysosomal degradation pathway, which degrades misfolded proteins, removes unnecessary or damaged organelles and eliminates intracellular pathogens, such as viruses and bacteria, to maintain cellular homeostasis. Autophagy is critical for cell survival, bioenergetic homeostasis and organismal development, and is closely associated with many human diseases. This review summarizes current advances in the role of autophagy in cancer and neurodegenerative diseases, and discusses potential therapeutic approaches to target autophagy.

关 键 词：自噬 癌症 神经退行性疾病 自噬抑制剂 

分 类 号：R73[医药卫生—肿瘤]