干扰素-γ在肿瘤免疫中的双重角色:抗肿瘤与促肿瘤作用  

The Dual Role of Interferon-γ in Tumor Immunity: Anti-Tumor and Pro-Tumor Effects

作　　者：蓝轲 王思涵 宁仕勤 黄嘉丽 李晓泉 

机构地区：[1]广西医科大学第二临床医学院,广西 南宁 [2]广西医科大学基础医学院,广西 南宁 [3]广西医科大学基础医学院免疫学教研室,广西 南宁

出　　处：《生物过程》2025年第1期44-51,共8页Bioprocess

基　　金：本项目由广西医科大学大学生创新创业计划(202310598005)资助。

摘　　要：干扰素-γ (IFN-γ)作为II型干扰素家族的核心成员,在肿瘤免疫调控中扮演着复杂的角色。一方面,IFN-γ可诱导肿瘤细胞凋亡、抑制血管生成、增强抗原呈递及细胞毒性T细胞功能,发挥显著的抗肿瘤作用。另一方面,低剂量或持续性的IFN-γ信号可促进肿瘤干细胞特性、上皮–间质转化(EMT)及免疫检查点分子(如PD-L1)的表达,加剧肿瘤转移与免疫逃逸。本文系统地综述了IFN-γ的双向调控机制,IFN-γ与巨噬细胞、T细胞及抗原呈递细胞的动态相互作用,及IFN-γ免疫检查点抑制剂治疗中的关键作用。IFN-γ相关基因的表达水平与免疫治疗疗效密切相关,但其促肿瘤特性却限制其在临床中的应用。未来研究需进一步解析IFN-γ在肿瘤微环境中的作用,探索其靶向调控信号通路的策略,以优化癌症免疫治疗的精准性与安全性。本文为理解IFN-γ的免疫调控网络及其在肿瘤治疗中的应用提供了新的视角。Interferon-γ (IFN-γ), a core member of the type II interferon family, plays a complex dual role in tumor immune regulation. On one hand, IFN-γ can induce apoptosis in tumor cells, inhibit angiogenesis, enhance antigen presentation, and promote cytotoxic T cell function, thereby exerting significant anti-tumor effects. On the other hand, low doses of IFN-γ or persistent IFN-γ signaling may exacerbate tumor metastasis and immune escape by promoting stem cell characteristics, epithelial-to-mesenchymal transition (EMT), and the expression of immune checkpoint molecules such as PD-L1. This paper systematically reviews the bidirectional regulatory mechanisms of IFN-γ, dynamic interactions with macrophages, T cells, and antigen-presenting cells, as well as its critical role in immune checkpoint inhibitor therapy. Research indicates that the expression levels of IFN-γ-related genes are closely related to the efficacy of immunotherapy, but its protumor characteristics may limit clinical benefits. Future studies s

关 键 词：干扰素-γ (IFN-γ) 肿瘤免疫 免疫检查点抑制剂 JAK/STAT信号通路 免疫逃逸 肿瘤微环境 

分 类 号：R730.3[医药卫生—肿瘤]