免疫细胞功能检测在恶性肿瘤患者外周血中的表达和临床意义  

Expression of Immune Cell Function in Peripheral Blood of Patients with Malignant Tumor and Its Clinical Significance

作　　者：葛琴[1] 谢国栋[1] 蔡晶[1] 赵季忠[1] 刘继斌[2] 杨百霞[1] 崔娟娟[1] 储春霞[1] 

机构地区：[1]南通市肿瘤医院放疗科,江苏南通 [2]南通市肿瘤医院生物治疗中心,江苏南通

出　　处：《生物医学》2017年第3期54-58,共5页Hans Journal of Biomedicine

摘　　要：目的:通过检测恶性肿瘤患者外周血免疫细胞计数的变化,探讨其在肿瘤患者诊疗中的临床价值。方法:测定60例肿瘤患者,其中食管癌20例,肺癌20例,鼻咽癌10例,其他肿瘤(包括喉癌1例、舌癌1例、乳腺癌3例、皮肤恶性黑色瘤1例、直肠癌4例)10例;及20名正常对照组外周血T淋巴细胞亚群百分比、B淋巴细胞百分比、NK细胞百分比,比较与正常对照组间差异。结果:肿瘤患者组外周血中总T淋巴细胞百分比CD3+、辅助诱导T淋巴细胞百分比CD4+、辅助抑制T淋巴细胞比值CD4+/CD8+与健康组比较明显下降(P 0.05)。肿瘤患者组总B淋巴细胞百分比、NK细胞百分比与对照组差异无统计学意义。结论:T淋巴细胞亚群是一种检测肿瘤患者免疫功能异常的较好方法,对监测病情和判断预后具有重要意义。Objective: To investigate the clinical value of immune cell in peripheral blood of patients with malignant tumor, and to explore its clinical value in the diagnosis and treatment of cancer patients. Methods: 60 cases of cancer patients, including 20 cases of esophageal cancer, lung cancer in 20 cases, 10 cases of nasopharyngeal carcinoma, other tumors (including laryngeal cancer in 1 case, tongue cancer in 1 case, breast cancer in 3 cases, 1 case of skin malignant melanoma, rectal cancer 4 cases) and 20 normal control group peripheral blood T lymphocyte subsets percentage, B lymphocyte percentage, NK cell percentage, compared with the differences of normal control group. Results: The percentage of total T lymphocytes CD3+, assisted/induced T lymphocyte CD4+ and helped inhibited T lymphocyte ratio CD4+/CD8 in peripheral blood of tumor patients was significantly lower than that of healthy group (P 0.05). There was no significant difference between the percentage of total B lymphocytes and the percentage of NK cells in the tumor group and the control group. Conclusions: T lymphocyte subsets are a good method for detecting immune dysfunction in cancer patients, which are of great significance to monitor the disease and judge the prognosis.

关 键 词：肿瘤 免疫细胞 百分比 免疫功能 

分 类 号：R73[医药卫生—肿瘤]