人类核小体定位序列特征分析  

The Analysis of Human Nucleosome Location Sequences

作　　者：贾芸[1] 李宏 吕军[1] 王景峰[1] 

机构地区：[1]内蒙古工业大学理学院物理学系,内蒙古呼和浩特 [2]内蒙古大学物理科学与技术学院,内蒙古呼和浩特

出　　处：《生物医学》2018年第4期55-61,共7页Hans Journal of Biomedicine

基　　金：内蒙古工业大学重点研究项目(ZD201614)。

摘　　要：高通量体外实验证实DNA序列是影响核小体定位的重要因素,DNA序列之间的差异能够影响核小体定位的能力。本工作以人类基因组序列为研究对象,分析了人类核小体定位序列的组分特征,k-mer位置偏好等,统计结果显示核小体定位序列单核苷酸G和C的含量明显高于A和T,发现核小体定位序列中GC含量显著高于AT含量,并且出现频率较低的模体可能是核小体定位序列的特征模体。High-throughput experiments in vitro have confirmed that DNA sequences are important factors influencing nucleosome localization, and differences between DNA sequences can affect the ability of nucleosomes to localize. In this paper, we analyzed the sequence features of the nucleosomal localization sequences, k-mer position preference, and so on. The results showed that the content of nucleotides G and C was significantly higher than that of A and T in the nucleosome mapping sequence. The GC content in the nucleosome localization sequence was significantly higher than that in the AT, and the lower frequency motifs may be the characteristic motif of the nucleosome localization sequence.

关 键 词：模体 含量 核小体 序列 定位 影响 人类 

分 类 号：R73[医药卫生—肿瘤]