伤口愈合过程中热休克蛋白的功能研究  

Study of Heat Shock Proteins during Wound Healing

作　　者：乔翰超 唐能强 刘宇杰 杨伟 梁宇君[1] 

机构地区：[1]中国海洋大学海洋生命学院,发育与再生实验室,山东青岛

出　　处：《生物医学》2019年第2期63-69,共7页Hans Journal of Biomedicine

基　　金：山东省自然科学基金(ZR2012CM030)。

摘　　要：热休克蛋白广泛存在于各种生物体内,当生物体受到外界环境刺激后会大量表达,帮助生物体维持细胞的稳态。近期研究表明,热休克蛋白在伤口愈合过程中有促进细胞迁移的功能,通过向动物注射热休克蛋白能加速伤口的愈合过程,并且在高血糖环境下不受到阻碍。本综述通过查阅近年来相关资料,将热休克蛋白与传统的生长因子做了对比,描述了热休克蛋白90的功能和信号通路,总结了热休克蛋白在治疗伤口愈合过程中的优势和面临的困境。为将来研究伤口愈合的新药提供思路。Heat shock proteins are widelypresent in various organisms.When organisms are stimulated by the externalenvironment,they are expressed in large amounts,helping the organismsmaintain the homeostasis of the cells.Recent studies have shown that heatshock proteins have a function of promoting cell migration during woundhealing.By injecting heat shock proteins into animals,the healing process ofwounds can be accelerated and unobstructed in a hyperglycemic environment.Thisreview compares heat shock proteins with traditional growth factors,describesthe function and signaling pathways of heat shock protein 90,and summarizesthe advantages and disadvantages of heat shock proteins in the treatment ofwound healing,providing ideas for future research on new drugs for woundhealing.

关 键 词：热休克蛋白 伤口愈合 细胞迁移 eHsp90α 

分 类 号：R73[医药卫生—肿瘤]