肝炎病毒对NF-κB信号通路的调控作用  

Regulation of NF-Kappa B Signaling Pathway by Hepatitis Viruses

作　　者：王文静 龚石林 禹文海[2] 黄芬 

机构地区：[1]昆明理工大学医学院,云南 昆明 [2]中国医学科学院医学生物学研究所,云南 昆明

出　　处：《生物医学》2020年第3期35-42,共8页Hans Journal of Biomedicine

摘　　要：先天免疫应答是机体抵抗病毒感染的第一道防线。NF-κB信号通路作为先天免疫应答的重要部分,能够通过促进多种细胞因子产生而抵抗病原体的入侵。病毒可通过抑制NF-κB表达,逃逸宿主免疫反应,而有些病毒则可利用NF-κB的活化,促进自身的复制。肝炎病毒是引起病毒性肝炎的一大类病原体。目前,有关肝炎病毒对NF-κB信号通路的调控还没有系统的文献报道,本文将就乙型、丙型、丁型、戊型四种肝炎病毒对NF-κB信号通路的调控进行综述。The innate immune response is the first line of host against viral infection. As an important part of the innate immune response, NF-kappa B (NF-κB) signaling pathway can protect host against patho-gen invasion by activating the production of cytokines. Viruses can inhibit the expression of NF-κB by escaping the host immune response, while some viruses can use the activation of NF-κB to promote replication. Hepatitis viruses are the major pathogens of viral hepatitis. Up to now, there is no comprehensive report about the relationship between hepatitis viruses and NF-κB signaling pathway. The regulation of NF-κB signaling pathway during hepatitis viruses (B, C, D and E) infection was summered to clarify the interaction between NF-κB signaling pathway and hepatitis viruses.

关 键 词：肝炎病毒 NF-ΚB信号通路 先天免疫 免疫逃逸 

分 类 号：R73[医药卫生—肿瘤]