辅因子NAD 再生方法的研究进展  

Advances in Cofactor NAD Regeneration Methods

作　　者：肖汀 陈建华[1] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏 南京

出　　处：《生物医学》2024年第2期260-266,共7页Hans Journal of Biomedicine

摘　　要：辅因子在酶进行高效催化反应中扮演着不可或缺的角色,辅因子再生是指将在氧化还原酶催化过程中消耗的氧化型辅酶或还原型辅酶之间进行相互转化,以维持辅酶剂量水平的相对稳定,从而不断地促进底物分子朝着目的产物转化。鉴于辅因子的高成本、化学计量使用和物理不稳定性,合适的辅因子再生方法对于实际应用至关重要。因此,越来越多的研究人员着力开发多种高效经济的辅因子再生方法,以期更好地提高催化反应效率。本文主要对目前辅因子NAD 再生方法的研究进展进行综述,分析讨论各种方法的特点和研究现状,为辅因子在工业生产及医药应用领域的研究提供参考。Cofactors play an indispensable role in the efficient catalytic reactions carried out by enzymes, and cofactor regeneration refers to the interconversion of oxidized or reduced cofactors consumed in the catalytic process of redox enzymes to maintain a relatively stable coenzyme dose level, thus continuously facilitating the conversion of substrate molecules toward the target products. Given the high cost, stoichiometric use and physical instability of cofactors, suitable cofactor regeneration methods are crucial for practical applications. Therefore, more and more researchers are focusing on the development of various efficient and economical cofactor regeneration methods in order to better improve the efficiency of catalytic reactions. In this paper, we mainly review the current research progress of cofactor NAD regeneration methods, analyze and discuss the characteristics and current research status of various methods, and provide a reference for the research of cofactor in industrial production and pharmaceutical applications.

关 键 词：生物催化 NAD 再生 

分 类 号：G63[文化科学—教育学]