两个重要的高血压个体化用药相关基因多态位点及检测方法的研究进展  

Advances in Polymorphic Loci and Detection Methods for Two Important Hypertension Individualized Medication-Related Genes

作　　者：魏晓纯 何震宇[2] 

机构地区：[1]广东药科大学临床药学院,广东 广州 [2]广东药科大学基础医学院,广东 广州

出　　处：《生物医学》2024年第2期298-305,共8页Hans Journal of Biomedicine

摘　　要：高血压病是最常见的慢性心血管病,市场上降压药物种类众多,但不同个体相关的药物代谢基因存在多态性,导致疗效千差万别。CYP2C9基因1075 A > C位点和ADRB1基因1165 G > C位点是对高血压治疗药物疗效有重要影响的两个位点,本文对其临床意义、检测方法进行综述。Hypertension is the most common chronic cardiovascular disease, and there are many types of antihypertensive drugs on the market, but there are polymorphisms in the drug metabolism genes associated with different individuals, resulting in a wide range of therapeutic efficacy. 1075 A > C locus of CYP2C9 gene and 1165 G > C locus of ADRB1 gene are the two loci that have an important influence on the efficacy of antihypertension drugs, and this paper provides a review of their clinical significance, and the methods used to detect them.

关 键 词：CYP2C9基因 ADRB1基因 基因多态性 基因检测 

分 类 号：R54[医药卫生—心血管疾病]