桃核承气汤干预非小细胞肺癌脑转移瘤的体内药效学研究进展  

Research Progress of in Vivo Pharmacodynamics of Brain Metastasis from Non-Small Cell Lung Cancer Interfered by Taohe Chengqi Decoction

作　　者：杨丽姣[1] 严永兴[2] 董晓巧[3] 李鹏[2] 武文静[4] 

机构地区：[1]杭州市第三人民医院药剂科,浙江 杭州 [2]杭州市第三人民医院神经内科,浙江 杭州 [3]杭州市第一人民医院神经外科,浙江 杭州 [4]杭州市第三人民医院肛肠科,浙江 杭州

出　　处：《药物化学》2020年第3期84-89,共6页Hans Journal of Medicinal Chemistry

摘　　要：国内外研究现状对肺癌脑转移的发生发展,肺癌脑转移的中医认识,肺癌脑转移的治疗现状进行阐述。桃核承气汤加减方对脑胶质瘤细胞的增殖和侵袭有显著抑制作用;体内实验证明该方可以使荷瘤小鼠延长生存期。肺癌脑转移的病因病机复杂多样,与风之“变、动、快”特性一致。肺癌初期,正气亏损,风邪易犯,兼夹痰、瘀、毒上扰脑窍,聚而为瘤;后期因治疗及瘤体本身消耗,导致人体阴阳俱损、气失调畅,或肝逆动风,或脾虚生风,加重病情。在中医理论指导下,应用桃核承气汤对证干预肺癌脑转移瘤具有较高的可行性和较好的应用前景。Research progress of the brain metastasis from non-small cell lung cancer would be elaborated, in-cluding the development, Chinese medical cognition and current status of treatment. Taohe Chengqi Decoction could dramatically inhibit the proliferation and invasion of brain glioma cells. It was demonstrated in in vivo experimentation that Taohe Chengqi Decoction could extend the lifetime of tumor-bearing rats. The cause and mechanism of lung cancer with brain metastases complex, re-sembling to the “change, movement and swiftness”, the character of wind. In the early stage of lung cancer, the deficiency of positive qi, the tendency of wind evil to commit, and the tumor forms com-bine with phlegm, blood stasis and toxin, and accumulation of tumor. In the later stage, the treat-ment and consumption of the tumor itself lead to the loss of both yin and yang of human body, the unobstructed qi, or the reverse of the liver to move the wind, or the deficiency of the spleen to gen-erate wind, thus aggravating the illness. It has high feasibility and application prospect that Taohe Chengqi Decoction can interfere the brain metastasis from non-small cell lung cancer.

关 键 词：肺癌 脑转移 桃核承气汤 作用机制 

分 类 号：R73[医药卫生—肿瘤]