吡唑类化合物的合成及抗肿瘤活性分析  

Synthesis and Antitumor Activity Analysis of Pyrazole Compounds

作　　者：王玉琳 周庆发 

机构地区：[1]中国药科大学理学院,江苏 南京

出　　处：《药物化学》2022年第2期122-132,共11页Hans Journal of Medicinal Chemistry

摘　　要：吡唑是一类具有多种生理学活性的含氮五元杂环。在过去的十年里,越来越多的研究表明吡唑环类化合物可通过影响细胞分裂过程中关键酶,以及对特定肿瘤细胞系的抗增殖效应从而达到优秀的抗肿瘤效果。为进一步研究吡唑衍生物的抗肿瘤性质及其构效关系,以便充分开发这些化合物的抗肿瘤潜力,我们总结了合成吡唑及其衍生物的策略,并证明了这类化合物可以靶向发现新的抗肿瘤药物。Pyrazoles are a class of nitrogen-containing five-membered heterocycles with various physiological activities. In the past decade, more and more studies have shown that pyrazole compounds can achieve excellent antitumor effects by affecting key enzymes in the process of cell division and an-tiproliferative effects on specific tumor cell lines. To further study the antitumor properties of py-razole derivatives and their structure-activity relationships in order to fully exploit the antitumor potential of these compounds, we summarize strategies for the synthesis of pyrazoles and their de-rivatives, and demonstrate that such compounds can be targeted for discovery of new antitumor drugs.

关 键 词：吡唑 吡唑衍生物 抗肿瘤活性 

分 类 号：R914[医药卫生—药物化学] R96[医药卫生—药学]