角膜上皮干细胞的功能定位及其与眼表疾病的关系  

The Function and Localization of Corneal Epithelial Stem Cells and Its Relationship with Ocular Surface Diseases

作　　者：范军华 

机构地区：[1]解放军第910医院眼科中心,福建 泉州

出　　处：《眼科学》2019年第4期127-133,共7页Hans Journal of Ophthalmology

摘　　要：角膜上皮干细胞具有更新修复角膜上皮的重要功能,其定位于角膜缘受到广泛认可,但有越来越多的研究表明,不管是通过特异性标识物定位还是功能定位,都无法证实角膜上皮干细胞仅位于角膜缘,角膜缘干细胞在角膜上皮更新修复方面起到的作用有限。本文通过对角膜上皮干细胞研究的不同观点和证据的阐述,对近年来有关角膜上皮干细胞的功能定位及其与眼表疾病的关系研究作一综述。Corneal epithelial stem cells (CESCs) play an important role in repairing corneal epithelium. Their localization in limbus corneae has been widely recognized. However, more and more studies show that no matter through specific markers or functional localization, it cannot be confirmed that corneal epithelial stem cells are located only in limbus, and limbus stem cells play a limited role in renewal and repair of corneal epithelial. This article reviews the different viewpoints and evidences of corneal epithelial stem cells research, and summarizes the recent studies about the function and the localization of corneal epithelial stem cells and the relationship with ocular surface diseases in recent years.

关 键 词：角膜上皮干细胞 角膜缘干细胞 眼表疾病 角膜缘干细胞功能障碍 

分 类 号：R73[医药卫生—肿瘤]