圆锥角膜的非遗传性病因研究进展  

Research Progress on Non-Hereditary Etiology of Keratoconus

作　　者：刘美婵 何书喜[1] 彭昌福[1] 

机构地区：[1]湖南师范大学附属第一医院,湖南 长沙

出　　处：《眼科学》2022年第1期83-88,共6页Hans Journal of Ophthalmology

摘　　要：圆锥角膜(Keratoconus)是一种表现为角膜呈圆锥状突起,突起区角膜基质变薄,导致进行性视力下降、散光增加的疾病。既往认为其发病机制主要由遗传因素决定。现代研究发现,其发病不仅与遗传有关,还可能与炎症因子水平、环境、变态反应等有着密切联系。本文就圆锥角膜的非遗传性病因研究进展(眼的机械摩擦、过敏反应、紫外线照射等)进行综述,为圆锥角膜的多元化提供相关理论依据。Keratoconus (Keratoconus) is a disease characterized by a cone-shaped protrusion of the cornea and thinning of the corneal stroma in the protrusion area, resulting in progressive vision loss and increased astigmatism. It was previously thought that its pathogenesis was mainly determined by genetic factors. Modern research has found that its pathogenesis is not only related to heredity, but may also be closely related to the level of inflammatory factors, the environment, and allergic reactions. This article reviews the research progress of non-hereditary causes of keratoconus (mechanical friction of the eye, allergic reactions, ultraviolet radiation, etc.), and provides relevant theoretical basis for the diversification of keratoconus.

关 键 词：圆锥角膜 变态反应 炎症因子 紫外线照射 

分 类 号：G63[文化科学—教育学]