后发性白内障相关细胞因子及其信号通路研究进展  

Advances in the Study of Cytokines and Their Signaling Pathways Associated with Posterior Cataract

作　　者：胡亚茹 谢尚论 王剑锋[1] 

机构地区：[1]蚌埠医学院第一附属医院眼科,安徽 蚌埠 [2]蚌埠医学院生命科学院,安徽 蚌埠

出　　处：《眼科学》2022年第2期193-200,共8页Hans Journal of Ophthalmology

摘　　要：后发性白内障又称后囊膜混浊(posterior capsular opacification,PCO),是白内障患者手术后最常见的并发症。白内障囊外摘除、人工晶体植入术后残留部分晶状体上皮细胞(lens epithelial cells,LECs)发生增殖,并逐渐向后囊膜迁移,由上皮表型转化为间充质表型(epithelial mesenchymal transformation,EMT),同时产生大量的胶原和纤连蛋白等细胞外基质(extracellular matrix,ECM),最终导致后囊膜混浊和纤维化。PCO的发生和发展与多种细胞因子的调节有关,其中研究最广泛的参与诱导PCO的细胞因子是TGF-β。本文就这些细胞因子及其参与的信号调控通路进行综述,以期为临床防治PCO提供新型分子生物学研究靶点,探寻更有效的防治方法,展望更广阔的研究前景。Posterior capsular opacification (PCO) is the most common reason of postoperative visual loss in cataract patients. After surgery of extracapsular cataract extraction and intraocular lens implantation, the remained LECs proliferate, migrate into posterior capsular, and the epithelial phenotype of lens epithelial cells gradually turns into mesenchymal phenotype (epithelial mesenchymal transformation, EMT). At the same time, a large amount of extracellular matrix (ECM) such as collagen and fibronectin is produced, resulting in posterior capsular opacity and fibrosis. The occurrence and development of PCO are related to the regulation of various cytokines, of which TGF-β is the most widely studied factor involved in PCO induction. In this review, we reviewed the cytokines and regulatory pathways related to PCO. In order to provide new molecular biological research targets for the clinical control of PCO, to explore more effective control methods, and to look forward to a broader research prospect.

关 键 词：后发性白内障 晶状体上皮细胞 细胞因子及其相关信号通路 

分 类 号：R73[医药卫生—肿瘤]