青光眼对不同区域视网膜神经纤维层厚度与光反射信号的影响研究  

Study on the Impacts of Glaucoma on the Thickness and Light Reflectivity of Retinal Nerve Fiber Layer in Different Regions

作　　者：陈适蓉 杨剑玲 陈镔瑶[1] 

机构地区：[1]汕头大学·香港中文大学联合汕头国际眼科中心,广东 汕头

出　　处：《眼科学》2024年第4期142-150,共9页Hans Journal of Ophthalmology

基　　金：广东省普通高校青年创新人才项目(2020KQNCX022)

摘　　要：目的:利用光相干断层扫描(OCT)研究不同区域视网膜神经纤维层(RNFL)厚度与光反射信号值在青光眼中的变化情况。方法:病例对照研究。纳入49名健康受试者的49只眼及47名青光眼患者的47只眼进行以视盘为中心的三维OCT扫描。在半径为1.7 mm、1.95 mm和2.2 mm的3个分析环下,导出视盘周围环形截面图像,然后通过Image J软件进行分析。对比两组间不同半径,分析环下不同象限RNFL厚度及光反射信号的改变。结果:青光眼组RNFL在不同分析半径不同象限下的厚度值及光反射信号值基本较对照组低(p t检验),其中在下方象限中两组厚度差别最大;在颞侧象限中光反射信号值差别最大。大部分区域RNFL厚度与视野MD呈中至高度正相关(p p p均 p均 Objective: To investigate the changes in the thickness of the retinal nerve fiber layer (RNFL) and light reflectivity in different regions in eyes with glaucoma using optical coherence tomography (OCT). Methods: A case-control study was conducted, including 49 eyes from 49 healthy subjects and 47 eyes from 47 glaucoma patients for three-dimensional OCT scans centered on the optic disc. Circular peripapillary sections were extracted at radii of 1.7 mm, 1.95 mm, and 2.2 mm and then analyzed using Image J software. The changes in RNFL thickness and light reflectivity in different quadrants under different radii of analysis rings were compared between the two groups. Results: The thickness and light reflectivity of the RNFL in the glaucoma group were generally lower than those in the control group at different analysis radii and in different quadrants (p t-test), with the greatest difference in thickness in the inferior quadrant and the greatest difference in light reflectivity in the temporal quadrant. The RNFL thickness in most areas showed a moderate to high positive correlation with visual field mean deviation (MD) (p p p p < 0.05). Conclusion: The light reflectivity of the RNFL in different regions reflects the

关 键 词：光反射信号 青光眼 视网膜神经纤维层 光相干断层扫描 

分 类 号：R73[医药卫生—肿瘤]