维生素C对糖尿病小鼠视网膜的保护作用  

The Protective Effect of Vitamin C on the Retina of Diabetic Mice

作　　者：胡彬 田艳明 

机构地区：[1]石河子大学医学院,新疆 石河子 [2]新疆军区总医院眼科,新疆 乌鲁木齐

出　　处：《眼科学》2025年第1期57-62,共6页Hans Journal of Ophthalmology

基　　金：新疆维吾尔自治区自然科学基金面上项目(2022D01C647)。

摘　　要：糖尿病视网膜病变(Diabetic Retinopathy, DR)是糖尿病的主要微血管并发症,慢性炎症和细胞凋亡在其发生发展中起关键作用。研究表明,维生素C具有抗氧化和抗炎特性,可能有助于缓解DR相关的视网膜损伤。然而,其在DR体内模型中的保护作用仍不明确。本研究采用链脲佐菌素(Streptozotocin, STZ)诱导糖尿病小鼠模型,检测维生素C干预对视网膜组织结构及炎症因子表达的影响。结果表明,维生素C通过减少TNF-α、IL-1β、IL-6和MCP-1的表达水平,减轻炎症反应,同时抑制视网膜神经细胞凋亡并改善视网膜厚度。研究揭示了维生素C可能通过抗炎和抗凋亡机制对DR产生保护作用,为其作为辅助治疗提供了实验依据。Diabetic retinopathy (DR) is a major microvascular complication of diabetes, with chronic inflammation and cell apoptosis playing key roles in its pathogenesis. Vitamin C has antioxidant and anti-inflammatory properties, and may help alleviate retinal damage associated with DR. However, its protective effects in DR animal models are still unclear. In this study, a STZ-induced diabetic mouse model was used to examine the impact of vitamin C intervention on retinal tissue structure and inflammatory cytokine expression. The results showed that vitamin C significantly reduced the expression levels of TNF-α, IL-1β, IL-6, and MCP-1, alleviating inflammation, while inhibiting retinal neuronal cell apoptosis and improving retinal thickness. The study suggests that vitamin C may exert protective effects on DR through anti-inflammatory and anti-apoptotic mechanisms, providing experimental support for its use as an adjunctive therapy.

关 键 词：糖尿病视网膜病变 炎症 凋亡 维生素C 

分 类 号：R774.1[医药卫生—眼科]