晚期胃癌的现代治疗策略:综合评估与未来方向  

Modern Treatment Strategies for Advanced Gastric Cancer: Comprehensive Evaluation and Future Directions

作　　者：文燕秋 马金华[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院肿瘤内科,青海 西宁

出　　处：《临床个性化医学》2024年第2期199-205,共7页Journal of Clinical Personalized Medicine

摘　　要：晚期胃癌由于其高侵袭性和快速转移特性,成为临床治疗的难题。本综述深入探讨了晚期胃癌的现代治疗策略,包括化疗、放疗、靶向疗法和免疫治疗等多种方法。在化疗方面,新型药物组合及个体化治疗方案的开发提高了治疗效果。放疗技术的创新,如强度调制放疗,提高了治疗的精准度。靶向疗法针对特定分子标志物,展示了针对性治疗的潜力,而免疫治疗则通过激活患者的免疫系统攻击癌细胞,开辟了新的治疗途径。个体化治疗策略,通过分子分型和生物标志物的识别,为患者提供了更精准的治疗选择。同时,治疗方案的定制化与优化,包括药物剂量调整和联合疗法的应用,进一步提高了治疗的有效性和安全性。此外,本文还强调了患者生活质量的管理,包括控制和缓解治疗副作用,以及提供心理支持和生活方式调整,以改善患者的整体福祉。新兴技术的探索,如生物标志物研究进展、新型药物和治疗策略的开发,以及临床试验的进行,为晚期胃癌治疗带来了新的希望和方向。总体而言,综合利用多种治疗手段,结合个体化治疗策略,是未来提高晚期胃癌患者生存率和生活质量的关键。Advanced gastric cancer, with its high invasiveness and rapid metastatic characteristics, poses a significant challenge in clinical treatment. This review thoroughly explores modern treatment strategies for advanced gastric cancer, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy. In chemotherapy, the development of new drug combinations and individualized treatment plans has improved treatment outcomes. Innovations in radiotherapy, such as intensity-modulated radiation therapy, have enhanced the precision of treatment. Targeted therapy, focusing on specific molecular markers, has shown potential for specific treatment approaches, while immunotherapy opens new therapeutic avenues by activating the patient’s immune system to attack cancer cells. Individualized treatment strategies, based on molecular profiling and biomarkers, provide more precise treatment options for patients. Additionally, the customization and optimization of treatment plans, including adjustments in drug dosages and the use of combination therapies, further enhance the effectiveness and safety of treatments. Moreover, this article emphasizes the management of patients’ quality of life, including controlling and alleviating treatment side effects, as well as providing psychological support and lifestyle adjustments to improve overall well-being. The exploration of emerging technologies, such as the progress in biomarker research, development of new drugs and treatment strategies, and clinical trials, brings new hope and directions for the treatment of advanced gastric cancer. Overall, the comprehensive use of various treatment methods combined with individualized treatment strategies is key to improving the survival rate and quality of life of patients with advanced gastric cancer.

关 键 词：晚期胃癌 现代治疗策略 化疗进展 放疗技术 靶向疗法 免疫治疗 个体化治疗 生物标志物 治疗副作用管理 心理支持 

分 类 号：R73[医药卫生—肿瘤]