西酞普兰中毒致5-羟色胺综合征1例  

A Case of 5-Hydroxytryptamine Syndrome Caused by Citalopram Poisoning

作　　者：崔园园 刘雷[2] 李含 李静[3] 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院全科医学科,山东 济宁 [3]济宁医学院附属医院急诊科,山东 济宁

出　　处：《临床个性化医学》2024年第2期525-529,共5页Journal of Clinical Personalized Medicine

摘　　要：西酞普兰作为一种高选择性5-羟色胺再摄取抑制剂,临床广泛用于治疗抑郁症。5-羟色胺综合征是5-羟色胺大量蓄积导致中枢5-羟色胺能系统过度兴奋而出现的恶性综合征。西酞普兰过量致5-羟色胺综合征有潜在的致死风险,目前有关西酞普兰过量的临床数据有限,总体救治经验少,本文对1例因西酞普兰中毒致5-羟色胺综合征患者成功的诊治过程进行了回顾和分析,并参考了国内外相关文献,以期为今后的临床工作提供参考及借鉴。Citalopram, as a highly selective serotonin reuptake inhibitor, is widely used in the treatment of depression. 5-hydroxytryptamine syndrome is a malignant syndrome in which the central serotonin system is overexcited due to the accumulation of serotonin. There is a potential risk of death in serotonin syndrome caused by citalopram overdose. Currently, there are limited clinical data on citalopram overdose, and the overall treatment experience is limited. In this paper, the successful diagnosis and treatment process of a patient with serotonin syndrome caused by citalopram poisoning was reviewed and analyzed, and relevant literature at home and abroad was referred in order to provide reference for future clinical work.

关 键 词：西酞普兰 5-羟色胺综合征 药物中毒 

分 类 号：R74[医药卫生—神经病学与精神病学]