中医药基于NF-κB相关信号通路治疗溃疡性结肠炎的研究进展  

Research Progress in the Treatment of Ulcerative Colitis with Traditional Chinese Medicine Based on NF-κB Related Signaling Pathway

作　　者：郭冬奇 郑丽红[2] 

机构地区：[1]黑龙江中医药大学研究生院,黑龙江 哈尔滨 [2]黑龙江中医药大学附属第四医院,黑龙江 哈尔滨

出　　处：《临床个性化医学》2024年第4期1306-1313,共8页Journal of Clinical Personalized Medicine

摘　　要：溃疡性结肠炎(UC)是一种病因尚未明确的慢性非特异性肠道炎症性疾病,现实生活中常反复发作,病程缠绵难愈。值得注意的是其存在演变为结直肠恶性肿瘤的风险,而长期持续的慢性炎症刺激增加了这种风险,NF-κB通路是诱导机体肿瘤细胞及血管内皮细胞增生、侵袭及抑制细胞凋亡的重要因素信号途径作为调节肿瘤微环境的关键一环。目前,已有大量的临床及动物实验证明中医、中药可通过干预NF-κB相关信号通路达到减轻炎症反应,促进肠粘膜修复,维持肠道菌群生态平衡的目的,从而获得良好的治疗效果。本文就NF-κB相关通路与中医药对其干预的机制进行综述,以期为临床溃疡性结肠炎治疗提供借鉴与参考。Ulcerative colitis (UC) is a chronic and non-specific inflammation of the intestines with an unknown cause. The disease often presents as recurring attacks, making it difficult to cure. It is important to note that UC can progress into intestinal malignancy, and long-term chronic inflammation increases this risk. The NF-κB pathway plays a crucial role in promoting cell proliferation and invasion of tumor cells and vascular endothelial cells while inhibiting cell apoptosis, thereby influencing the tumor microenvironment. Numerous clinical and animal experiments have shown that traditional Chinese medicine interventions targeting the NF-κB signaling pathway can effectively reduce inflammation, promote intestinal mucosa repair, and restore ecological balance of the gut microbiota for optimal therapeutic outcomes in treating ulcerative colitis. This article reviews the NF-κB-related pathways and the intervention mechanism of traditional Chinese medicine in order to provide reference for clinical treatment of ulcerative colitis.

关 键 词：NF-ΚB 溃疡性结肠炎 中医药 

分 类 号：R73[医药卫生—肿瘤]