MTHFR基因多态性及其他相关因素与Hhcy的相关性研究  

Research on the Correlation between MTHFR Gene Polymorphism and Other Related Factors with Hhcy

作　　者：高雪莹 张迪[1] 孙博谦[1] 

机构地区：[1]北华大学附属医院神经内科,吉林 吉林

出　　处：《临床个性化医学》2024年第4期1659-1664,共6页Journal of Clinical Personalized Medicine

基　　金：吉林省教育厅科学技术研究项目(JJKH20210062KJ);吉林省发展和改革委员会项目(2021C018)。

摘　　要：目的:探讨亚甲基四氢叶酸还原酶(5, 10-methylenetetrahydrofolate reductase, MTHFR)基因多态性及其他相关因素与高同型半胱氨酸血症(hyper homocysteinermia, Hhcy)的相关性,为Hhcy防治提供数据支撑。方法:2017年11月至2019年10月,纳入北华大学附属医院神经内科就诊患者300例作为研究对象。以血浆同型半胱氨酸(homocysteinermia, Hcy)浓度15.4 umol/L为限定值,将患者分组为Hcy正常组(2检验及Logistic回归方法进行统计学分析,认定P 1),女性以及合并糖尿病是Hhcy发生的保护性因素(OR Objective: To investigate the correlation between MTHFR gene polymorphisms and other related factors and hyperhomocysteinemia (Hhcy), and to provide data support for the prevention and treatment of Hhcy. Methods: From November 2017 to October 2019, 300 patients admitted to the Neurology Department of the Affiliated Hospital of North China University were included as research subjects. The patients were divided into two groups according to the limit value of homocysteine (Hcy) in plasma (15.4 umol/L), with 135 cases in the normal Hcy group (2 test, and Logistic regression method were used for statistical analysis, with a P value of 1), while female gender and diabetes were protective factors for Hhcy (OR < 1). Conclusion: Advanced age (≥60 years) and a history of hypertension or the TT genotype of the MTHFR gene are risk factors for Hhcy.

关 键 词：高同型半胱氨酸血症 亚甲基四氢叶酸还原酶 基因多态性 

分 类 号：R74[医药卫生—神经病学与精神病学]