代谢组学:解锁生命奥秘与疾病治疗的新篇章  

Metabolomics: A New Chapter in Unlocking the Mysteries of Life and Disease Treatment

作　　者：白跃花 李若冰 王莉 林佳 

机构地区：[1]华北理工大学生命科学学院,河北 唐山

出　　处：《临床个性化医学》2024年第4期2538-2546,共9页Journal of Clinical Personalized Medicine

摘　　要：本文旨在概述代谢组学从概念萌芽至技术革新的发展历程,详尽探讨了其分析技术(如核磁共振、质谱及其联用技术)与数据处理手段的不断进步,并深入阐述了代谢组学在生命科学领域的广泛应用,特别是在基础研究与临床研究中的显著贡献。针对几类常见的疾病类型,包括癌症、心血管疾病及神经系统疾病,本文分别综述了代谢组学在这些疾病诊断、治疗研究中的最新进展与实际应用状况。最后,还对代谢组学的未来发展趋势进行了前瞻性的展望。This article aims to outline the development history of metabolomics from conceptual germination to technological innovation, discuss in detail the continuous advancement of its analytical technologies (such as nuclear magnetic resonance, mass spectrometry and their combination technologies) and data processing methods, and elaborate in depth the extensive application of metabolomics in the field of life sciences, especially its significant contribution in basic research and clinical research. Focusing on several common disease types, including cancer, cardiovascular diseases and nervous system diseases, this article reviews the latest progress and practical application of metabolomics in the diagnosis and treatment of these diseases. Finally, we make a forward-looking outlook on the future development trend of metabolomics.

关 键 词：代谢组学 癌症 心血管疾病 神经系统疾病 

分 类 号：R73[医药卫生—肿瘤]