噪声损伤模型中XIAP对耳蜗毛细胞保护的机制  

The Protective Mechanism of XIAP on Cochlear Hair Cells in Noise Damage Model

作　　者：闫琳 杨见明[1] 

机构地区：[1]安徽医科大学第二附属医院耳鼻喉头颈外科,安徽 合肥

出　　处：《临床个性化医学》2024年第4期2547-2552,共6页Journal of Clinical Personalized Medicine

基　　金：安徽医科大学研究生科研与实践创新项目(编号:YJS20230136)。

摘　　要：噪声是导致听力损失的常见原因之一。凋亡抑制蛋白XIAP被认为在众多IAPs家族成员中是最有效的细胞死亡调控因子。目前XIAP对耳蜗毛细胞保护的研究有很多,但主要是其抗凋亡作用,对于炎症方面并未进行深入探索。本研究将采用耳蜗毛细胞系进行探索,发现XIAP与炎症具有重要关系,我们发现通过过表达XIAP水平可以缓解炎症,从而减轻耳蜗毛细胞损伤,减少噪声所引起的听力损失,为临床上治疗噪声所引起的听力损失提供了新的靶点和治疗思路。Noise is one of the most common causes of hearing loss. X-linked inhibitor of apoptosis protein is considered to be the most potent regulator of cell death among many IAPs family members. At present, there are many studies on the protection of XIAP on cochlear hair cells, but the anti-apoptotic effect is the main one, and the inflammation aspect has not been deeply explored. In this study, cochlear hair cell lines will be used for exploration, and it is found that XIAP has an important relationship with inflammation. We found that overexpression of XIAP can alleviate inflammation, thereby reducing cochlear hair cell damage and hearing loss caused by noise, providing a new target and therapeutic idea for the clinical treatment of hearing loss caused by noise.

关 键 词：噪声性耳聋 毛细胞 X连锁凋亡抑制蛋白 

分 类 号：R73[医药卫生—肿瘤]