生物标记物在分子诊断中对靶向治疗的应用  

Application of Biomarkers for Common Cancers in Molecular Diagnosis

作　　者：韩建冬 王美玲[1] 额尔敦[1] 杜艳青[1] 梁凤英[1] 格根塔娜[1] 

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特

出　　处：《医学诊断》2019年第2期35-41,共7页Medical Diagnosis

摘　　要：目前可以从通过活组织检查或手术获得的肿瘤样本中收获肿瘤的DNA。可以使用高通量基因分型和或测序平台进行肿瘤DNA的完整分子谱分析。预测性生物标志物的鉴定将允许用特异性靶标(激酶抑制剂和MoAb,单克隆抗体)和常规药剂进行个体化治疗。但生物标记物在分子诊断中对靶向治疗的应用仍是分子诊断学中的关键,本文将概述生物标记物在分子诊断中对靶向治疗的关键应用。Tumor DNA can now be harvested from tumor samples obtained by biopsy or surgery.Complete molecular profiling of tumor DNA can be performed using high throughput genotyping and or se-quencing platforms.Identification of predictive biomarkers will allow for individualized treatment with specific targets(kinase inhibitors and MoAbs,monoclonal antibodies)and conventional agents.However,the application of biomarkers to targeted therapies in molecular diagnostics remains the key to molecular diagnostics.This article will outline the key applications of biomarkers for targeted therapies in molecular diagnostics.

关 键 词：分子 诊断 肿瘤 

分 类 号：R73[医药卫生—肿瘤]