预测性生物标记物在急性移植物抗宿主病中的研究进展  

Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

作　　者：徐艳军 易甜甜 吴学东[2] 

机构地区：[1]南方医科大学附属佛山妇幼保健院儿科,广东佛山 [2]南方医科大学南方医院儿科,广东广州

出　　处：《医学诊断》2019年第2期71-76,共6页Medical Diagnosis

基　　金：广东省科技计划项目2014A020212186;广州市科技计划项目201607010241。

摘　　要：急性移植物抗宿主病是异基因造血干细胞移植后不可避免遇到的棘手问题,临床上主要依靠临床表现及病理活检进行诊断。预测性生物标记物成为近年来研究热点,多中心共同研究成为必然趋势,本文对近年来国内外预测性生物标记物的研究进行总结归纳,主要包括对基因、蛋白质及细胞水平的研究。Acute graft-versus-host disease(aGVHD)is the primary source of morbidity and mortality after HSCT.Diagnosis of aGVHD is typically based on clinical symptoms and confirmed by biopsy.In this review,we aim to summarize some of the recent developments of biomarkers in the field of al-lo-HSCT,including miRNAs,Cellular biomarkers,Proteomic biomarkers and biomarker panels.At present,the research of biomarkers has become a hotspot.However,predictive biomarkers still require a coordinated multicenter approach with coordinated times of sampling and centralized analysis of biomarker levels.

关 键 词：异基因造血干细胞移植 急性移植物抗宿主病 生物标记物 

分 类 号：R73[医药卫生—肿瘤]