铋基纳米材料的制备及其在肿瘤诊疗中的研究进展  

Research Progress in Preparation and Theranostics of Bismuth-Based Nanomaterials

作　　者：向桓冬 邓苗[1] 晏亮[2] 

机构地区：[1]成都理工大学材料与化学化工学院,四川 成都 [2]中国科学院高能物理研究所,中国科学院纳米生物效应安全性重点实验室,北京

出　　处：《纳米技术》2021年第2期19-26,共8页Hans Journal of Nanotechnology

摘　　要：随着纳米技术的快速发展,以纳米材料为基础的新型生物材料在生物医学领域表现出独特的优势,因而受到研究人员的广泛关注。铋(bismuth, Bi)基纳米材料因其良好的生物相容性和优异的光学、电学等物理化学特性,在药物递送、抗菌、组织工程、生物传感、肿瘤治疗等生物医学领域的应用已被广泛研究和报道;特别地,在生物成像及癌症诊疗方面展现出广阔的应用潜力。本文结合实例简要综述了生物医用铋基纳米材料的常见类型和制备方法,总结了其在计算机断层扫描(CT)成像、光声(PA)等生物成像和光热治疗、放射治疗等肿瘤诊疗中的最新研究进展,并在此基础上对其在生物医学中的应用前景进行了展望和对挑战展开了分析。With the rapid development ofnanotechnology, the novel nanomaterial-based biomaterials can effectivelyovercome the disadvantages resulted from traditional biomaterials to promotethe development of biomedicine, therefore have received wide attention from researchers.Because of their good biocompatibility and excellent physicochemical propertiessuch as optical, electrical and magnetic characteristics, bismuth-basednanomaterials have been extensively studied and reported in biomedical fieldssuch as drug delivery, antibacterial, tissue engineering, biosensors, tumortreatment, especially in bioimaging and theranostics applications. Combinedwith the reported studies, this paper briefly reviews the common types andsynthesis methods of biomedical bismuth-based nanomaterials, and summarizes thelatest research progress in bioimaging (such as computed tomography (CT) andphotoacoustic imaging) and in theranostics (such as photothermal therapy (PTT)and radiotherapy). Finally, on this basis the prospects and challenges ofbismuth-based nanomaterials for the biomedical applications in the future areexpected.

关 键 词：铋基纳米材料 生物医学 生物成像 肿瘤诊疗 

分 类 号：R73[医药卫生—肿瘤]