5-羟色胺1受体、5-羟色胺转运体与酒精依赖综合征关联研究进展  

Research Progress on the Association between Serotonin 1 Receptor, Serotonin Transporter and Alcohol Dependence Syndrome

作　　者：黎宽 张柠 阮冶[2] 鲍建军[2] 张旭兰[2] 杨朔 赵斐 卢晓筱 杨晓佩 钟树荣 

机构地区：[1]昆明医科大学法医学院,云南 昆明 [2]云南省精神病医院,昆明医科大学附属精神卫生中心,云南 昆明 [3]江西神州司法鉴定中心,江西 南昌 [4]楚雄医药高等专科学校,云南 楚雄 [5]昆明医科大学司法鉴定中心,云南 昆明

出　　处：《自然科学》2021年第5期732-738,共7页Open Journal of Nature Science

摘　　要：酒精依赖综合征指反复大量饮酒引起的特殊心理状态,表现为对酒精的渴求和经常需要饮酒的强迫性体验,是饮酒导致酒精的精神和躯体依赖。有害使用酒精已成为世界范围内致病、致残和致死的五大风险因素之一,给社会造成严重的经济负担。研究表明酒精依赖综合征与遗传因素相关联。本文综述了遗传基因多态性与酒精依赖综合征患者关联的研究进展,分析了两者间形成关联的可能机制,提出了目前研究存在的局限性以及未来的研究方向,为酒精依赖综合征的预防控制提供科学依据。Alcohol dependence syndrome refers to a special psychological state caused by repeated heavy drinking, manifested as a thirst for alcohol and a compulsive experience of frequent need to drink, which is the mental and physical dependence of alcohol caused by drinking. Harmful use of alcohol has become one of the five major risk factors for disease, disability, and death worldwide, causing a serious economic burden on society. Studies have shown that alcohol dependence syndrome is associated with genetic factors. This article reviews the research progress on the association between genetic polymorphisms and alcohol dependence syndrome patients, analyzes the possible mechanism of the association between the two, and proposes the limitations of current research and future research direction, providing scientific basis for the prevention and control of alcohol dependence syndrome.

关 键 词：5-HTR 5-HTT 单核苷酸多态性 酒精依赖综合征 

分 类 号：R74[医药卫生—神经病学与精神病学]