酒精滥用对阿尔茨海默病发病机制雏探  

A Preliminary Study on the Mechanism of Alcohol Abuse in Alzheimer’s Disease

作　　者：徐加伟 车土玲 蓝萍 苏裕盛 

机构地区：[1]宁德师范学院医学院,福建 宁德 [2]宁德师范学院毒物与药物毒理学重点实验室,福建 宁德

出　　处：《自然科学》2023年第2期147-155,共9页Open Journal of Nature Science

摘　　要：阿尔茨海默病(Alzheimer disease, AD)是一种神经退行性疾病,主要表现为认知障碍。酒作为日常饮品虽能给人体带来益处,但过度饮酒将损害机体健康,目前研究成果展示由于酒精滥用会增加患AD的风险。为了探讨酒精对AD的作用机制,本文将通过AD的发病机制与酒精滥用对机体产生的危害进一步阐明酒精滥用对AD的影响。结果显示,酒精滥用将会导致机体产生炎症和氧化应激,而氧化应激又将进一步加重机体的炎症反应。此外,酒精滥用还会危害人体肠道微生物的数量及比例分布等,进而导致微生物生态失衡,不仅如此,肠道微生物还因酒精滥用导致炎症,这也将进一步危害机体的健康。又因氧化应激、炎症反应等又会加快AD的发病,所以由酒精滥用引起的氧化应激、炎症反应、肠道微生物失调等因素也能促进AD的发展。因此,控制酒精的摄取可能会在一定程度上减缓AD的发病,起到预防AD的作用。Alzheimer disease (AD) is a neurodegenerative disease, mainly manifested as cognitive impairment. Although alcohol as a daily drink can bring benefits to the human body, excessive drinking will damage the health of the body. The current research results show that alcohol abuse will increase the risk of AD. In order to explore the action mechanism of alcohol on AD, this article will further clarify the impact of alcohol abuse on AD through the pathogenesis of AD and the harm of alcohol abuse on the body. The results show that alcohol abuse will lead to inflammation and oxidative stress in the body, and oxidative stress will further aggravate the inflammatory reaction of the body. In addition, alcohol abuse will also harm the number and proportion of human intestinal microorganisms, which will lead to the imbalance of microbial ecology. In addition, intestinal microorganisms will also cause inflammation due to alcohol abuse, which will further endanger the health of the body. Because oxidative stress and inflammatory reaction will accelerate the onset of AD, factors such as oxidative stress, inflammatory reaction and intestinal microbial imbalance caused by alcohol abuse can also promote the development of AD. Therefore, controlling alcohol intake may slow down the onset of AD to a certain extent and play a role in preventing AD.

关 键 词：阿尔茨海默 酒精 氧化应激 炎症 

分 类 号：R74[医药卫生—神经病学与精神病学]