阿尔茨海默病化学合成药及生物技术药物药的研究进展  

Research Progress of Chemical Synthesis Drugs and Biotechnology Drugs for Alzheimer’s Disease

作　　者：陈学权 郑文彬 车土玲 聂奕玮 周文庆 苏裕盛 

机构地区：[1]宁德师范学院医学院,福建 宁德

出　　处：《自然科学》2024年第2期440-448,共9页Open Journal of Nature Science

摘　　要：阿尔茨海默病(Alzheimer’s Disease, AD)是最常见的与年龄相关的不可逆和进行性神经退行性疾病之一,其特征是失智、记忆力减退、语言技能下降以及随着年龄的增长而出现认知障碍。目前的治疗药物主要以改善临床症状为主,本文通过查阅相关文献,将主要与AD相关且受美国食品药物管理局(Food and Drug Administration, FDA)所批准的治疗药物做一综述,本文系统地总结和分析当前治疗药物在AD治疗中的作用以及研究进展,以此为AD的治疗和研究提供参考和借鉴。Alzheimer’s disease (AD) is one of the most common age-related irreversible and progressive neurodegenerative diseases, characterized by dementia, memory loss, decline in language skills, and cognitive impairment with age. Current therapeutic drugs are mainly used to improve clinical symptoms. This paper reviews the therapeutic drugs that are mainly related to AD and approved by the Food and Drug Administration (FDA) of the United States by referring to relevant literature. This article systematically summarizes and analyzes the role of current therapeutic drugs in the treatment of AD and the research progress in order to provide reference for the treatment and research of AD.

关 键 词：阿尔茨海默病 药物治疗 Β-淀粉样蛋白 乙酰胆碱 N-甲基天冬氨酸 阿杜卡单 

分 类 号：R74[医药卫生—神经病学与精神病学]